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Open AccessArticle

A Comparison of Constitutive and Inducible Non-Endogenous Keto-Carotenoids Biosynthesis in Synechocystis sp. PCC 6803

1
Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Via Bassini 15a, 20133 Milano, Italy
2
Photosynthesis Research Unit, Consiglio Nazionale delle Ricerche, Via Celoria 26, 20133 Milano, Italy
3
Istituto di Ricerca sulle Acque-Verbania, Consiglio Nazionale delle Ricerche, Largo Tonolli 50, 28933 Verbania, Italy
*
Authors to whom correspondence should be addressed.
Microorganisms 2019, 7(11), 501; https://doi.org/10.3390/microorganisms7110501
Received: 9 August 2019 / Revised: 14 October 2019 / Accepted: 26 October 2019 / Published: 28 October 2019
(This article belongs to the Special Issue The Emerging Role of Cyanobacteria in Green Biotechnology)
The model cyanobacterium Synechocystis sp. PCC 6803 has gained significant attention as an alternative and sustainable source for biomass, biofuels and added-value compounds. The latter category includes keto-carotenoids, which are molecules largely employed in a wide spectrum of industrial applications in the food, feed, nutraceutical, cosmetic and pharmaceutical sectors. Keto-carotenoids are not naturally synthesized by Synechocystis, at least in any significant amounts, but their accumulation can be induced by metabolic engineering of the endogenous carotenoid biosynthetic pathway. In this study, the accumulation of the keto-carotenoids astaxanthin and canthaxanthin, resulting from the constitutive or temperature-inducible expression of the CrtW and CrtZ genes from Brevundimonas, is compared. The benefits and drawbacks of the two engineering approaches are discussed. View Full-Text
Keywords: astaxanthin; canthaxanthin; keto-carotenoids; metabolic engineering; Synechocystis sp. PCC 6803 astaxanthin; canthaxanthin; keto-carotenoids; metabolic engineering; Synechocystis sp. PCC 6803
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MDPI and ACS Style

Menin, B.; Lami, A.; Musazzi, S.; Petrova, A.A.; Santabarbara, S.; Casazza, A.P. A Comparison of Constitutive and Inducible Non-Endogenous Keto-Carotenoids Biosynthesis in Synechocystis sp. PCC 6803. Microorganisms 2019, 7, 501.

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