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Open AccessReview

Inflammasomes as Targets for Adjuvants

1
Kazan Federal University, 420008 Kazan, Russia
2
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
3
University of Nevada, Reno, NV 89557, USA
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(4), 252; https://doi.org/10.3390/pathogens9040252
Received: 2 March 2020 / Revised: 27 March 2020 / Accepted: 28 March 2020 / Published: 30 March 2020
(This article belongs to the Special Issue Biomarkers and Pathogenesis of Infectious and Autoimmune Diseases)
Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed. View Full-Text
Keywords: vaccines; adjuvants; inflammasomes; innate immunity; cytokines vaccines; adjuvants; inflammasomes; innate immunity; cytokines
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Ivanov, K.; Garanina, E.; Rizvanov, A.; Khaiboullina, S. Inflammasomes as Targets for Adjuvants. Pathogens 2020, 9, 252.

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