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New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral Targets

Department of Animal Sciences, Auburn University, Auburn, AL 36849, USA
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Pathogens 2020, 9(11), 876; https://doi.org/10.3390/pathogens9110876
Received: 24 September 2020 / Revised: 20 October 2020 / Accepted: 22 October 2020 / Published: 24 October 2020
Intercellular communication occurring by cell-to-cell contacts and via secreted messengers trafficked through extracellular vehicles is critical for regulating biological functions of multicellular organisms. Recent research has revealed that non-coding RNAs can be found in extracellular vesicles consistent with a functional importance of these molecular vehicles in virus propagation and suggesting that these essential membrane-bound bodies can be highjacked by viruses to promote disease pathogenesis. Newly emerging evidence that coronaviruses generate non-coding RNAs and use extracellular vesicles to facilitate viral pathogenicity may have important implications for the development of effective strategies to combat COVID-19, a disease caused by infection with the novel coronavirus, SARS-CoV-2. This article provides a short overview of our current understanding of the interactions between non-coding RNAs and extracellular vesicles and highlights recent research which supports these interactions as potential therapeutic targets in the development of novel antiviral therapies. View Full-Text
Keywords: lncRNA; miRNA; extracellular vehicles; exosomes; ectasomes; COVID-19; SARS-CoV lncRNA; miRNA; extracellular vehicles; exosomes; ectasomes; COVID-19; SARS-CoV
MDPI and ACS Style

Wower, I.K.; Brandebourg, T.D.; Wower, J. New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral Targets. Pathogens 2020, 9, 876. https://doi.org/10.3390/pathogens9110876

AMA Style

Wower IK, Brandebourg TD, Wower J. New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral Targets. Pathogens. 2020; 9(11):876. https://doi.org/10.3390/pathogens9110876

Chicago/Turabian Style

Wower, Iwona K., Terry D. Brandebourg, and Jacek Wower. 2020. "New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral Targets" Pathogens 9, no. 11: 876. https://doi.org/10.3390/pathogens9110876

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