Special Issue "The Structure-to-Function Relationship of Long Non-coding RNAs in Various Biological Systems"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (1 January 2021).
Viruses have developed a plethora of strategies to modulate the cellular environment to benefit the pathogen replication. One of these tactics includes the production of viral long non-coding (lnc) RNAs. The representatives of this large and functionally versatile category of non-protein coding transcripts longer than 200 nucleotides have been shown to play essential roles in establishing the virus–host interaction, but also in regulating different biological processes. During viral life cycles, lncRNAs have been shown to enhance viral gene expression, support viral replication and genome packaging, boost virion release, sustain viral latency, and assist viral-induced cellular transformation. As mediators of gene expression, lncRNAs can give rise to small non-coding RNAs such as tRNAs, micro (mi)RNAs, and circular (circ) RNAs to enlarge their regulatory power. Moreover, lncRNAs can act as competing endogenous RNAs or “sponges” by targeting and sequestrating miRNA to protect specific mRNAs, and as a “bridge” that interlinks the replication and pathogenesis of different types of viruses. Due to their broad characteristics and profound influence, lncRNAs are expected to be novel targets for the modulation of all types of biochemical processes involved in virus-associated pathogenesis. Open-ended questions include how viral lncRNAs’ structure–function relationship contributes to cellular immune evasion, whether lncRNAs act as virulence factors, and how viral lncRNAs coordinate cellular processes to support the virus life cycle.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts in the research of viral long non-coding RNAs in human, animal, and plant model systems. Manuscripts submitted to this Special Issue are guaranteed to have a quick and fair review process. Potential topics for the Special Issue include, but are not limited to:
- Novel functions of viral lncRNAs in virus replication and pathogenesis;
- Long non-coding RNAs encoded by DNA and RNA viruses;
- Satellite RNAs;
Dr. Joanna Sztuba-Solinska
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- viral long non-coding RNAs
- viral pathogenesis
- RNA interactome