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Open AccessArticle

Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens

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Laboratorio 5, LEDEFAR, Unidad de Investigacion Multidisciplinaria, Facultad de Estudios Superiores (FES) Cuautitlan, Universidad Nacional Autonoma de Mexico (UNAM), Cuautitlan Izcalli 54714, Mexico
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Departamento de Medicina Veterinária Preventiva, Centro de Diagnóstico e Pesquisa em Patologia Aviária, Universidade Federal do Rio Grande do Sul, Porto Alegre RS 97105-900, Brazil
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Department of Poultry Science, University of Arkansas, Fayetteville, AR 72704, USA
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Departamento de Medicina y Zootecnia de Aves, Facultad de Medicina Veterinaria y Zootecnia, UNAM, Ciudad de Mexico 04510, Mexico
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Laboratorio 14, Alimentos, Micotoxinas y Micotoxicosis, Unidad de Investigacion Multidisciplinaria, FES Cuautitlan, UNAM, Cuautitlan Izcalli 54714, Mexico
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(4), 229; https://doi.org/10.3390/pathogens8040229 (registering DOI)
Received: 26 October 2019 / Revised: 7 November 2019 / Accepted: 8 November 2019 / Published: 10 November 2019
(This article belongs to the Section Animal Pathogens)
Two experimental models were conducted to evaluate and compare the effect of ascorbic acid (AA) or curcumin formulated in a solid dispersion (SD-CUR) as prophylactic or therapeutic alternatives to prevent or control S. Enteritidis (SE) infection in broiler chickens. In the prophylactic model, dietary administration of AA showed a significant reduction in SE counts in crop compared to the positive control (PC) group (p < 0.05), whereas in cecal tonsils (CT), SD-CUR significantly reduced SE recovery. Superoxide dismutase (SOD) activity was significantly higher in chickens supplemented with AA or SD-CUR, and total intestinal IgA levels were significantly lower in both treatments when compared to the PC group. Serum fluorescein isothiocyanate-dextran (FITC-d) levels were reduced by SD-CUR compared to PC, while AA presented significantly lower total aerobic bacteria. In the therapeutic model, only the dietary administration of AA significantly decreased SE in crop and CT on days 3 and 10 post-challenge. FITC-d levels were significantly lower in both treated groups in comparison to PC, but IgA levels were significantly reduced only by AA. The results suggest that dietary AA and SD-CUR have different modes of action to reduce SE intestinal colonization in two different challenge models in broiler chickens. View Full-Text
Keywords: Ascorbic acid; curcumin; chickens; Salmonella Enteritidis; intestinal integrity Ascorbic acid; curcumin; chickens; Salmonella Enteritidis; intestinal integrity
MDPI and ACS Style

Hernandez-Patlan, D.; Solis-Cruz, B.; Pontin, K.P.; Latorre, J.D.; Hernandez-Velasco, X.; Merino-Guzman, R.; Mendez-Albores, A.; Hargis, B.M.; Lopez-Arellano, R.; Tellez-Isaias, G. Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens. Pathogens 2019, 8, 229.

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