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Open AccessArticle

Prevalence of Infection and Antibiotic Susceptibility of Helicobacter pylori: An Evaluation in Public and Private Health Systems of Southern Chile

1
Center of Excellence in Translational Medicine, CEMT-BIOREN, Universidad de La Frontera, Temuco 4810296, Chile
2
Doctoral Program in Sciences, Specialty in Applied Cellular and Molecular Biology, Universidad de La Frontera, Temuco 4811230, Chile
3
Faculty of Science Health, Universidad Autónoma de Chile, Temuco 4800913, Chile
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Department of Internal Medicine, Universidad de La Frontera, Temuco 4781218, Chile
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Gastroenterology Unit of Clinica Alemana de Temuco, Temuco 4810297, Chile
6
Gastroenterology Unit of Hospital Hernan Henriquez Aravena, Temuco 4781151, Chile
7
Gastroenterology Unit of Hospital de Villarrica, Villarrica 4930000, Chile
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(4), 226; https://doi.org/10.3390/pathogens8040226 (registering DOI)
Received: 10 October 2019 / Revised: 31 October 2019 / Accepted: 2 November 2019 / Published: 9 November 2019
Helicobacter pylori colonizes half of the human population. Age, ethnicity, and socioeconomic status are factors that influence the prevalence of the infection. This is important in southern Chile, one of the most unequal regions in the world, where a significant difference in the health access of the population occurs due to the existence of two competing health systems. Moreover, in the last few years, current protocols of H. pylori eradication have shown high rates of resistance with reduced therapeutic efficacy. This study reported the epidemiology of infection and attempted to identify divergent points among the population beneficiaries of the two health care schemes in southern Chile. Biopsies from public (n = 143) and private (n = 86) health systems were studied. At the same time, clinical and sociodemographic factors were evaluated. H. pylori strains were obtained from gastric biopsies for culture and molecular testing. Antibiotic susceptibility was determined by the agar dilution method. Differences about ethnicity, rural residence, and education (p ≤ 0.05) were observed between beneficiaries of the two health systems. The prevalence of H. pylori was 45%, with no significant differences regardless of the socioeconomic conditions. The only identified risk factor associated with H. pylori infection was Mapuche ethnicity (OR (odds ratio) = 2.30). H. pylori showed high resistance rates, particularly against clarithromycin (40%), levofloxacin (43.1%), and metronidazole (81.8%). This study highlighted the importance of Mapuche ancestry as a risk factor in southern Chile and emphasized the need to search for new eradication strategies as well as further studies evaluating therapeutic efficacy. View Full-Text
Keywords: prevalence of Helicobacter pylori infection; public and private health systems; antibiotic resistance prevalence of Helicobacter pylori infection; public and private health systems; antibiotic resistance
MDPI and ACS Style

Oporto, M.; Pavez, M.; Troncoso, C.; Cerda, A.; Hofmann, E.; Sierralta, A.; Rios, E.; Coppelli, L.; Barrientos, L. Prevalence of Infection and Antibiotic Susceptibility of Helicobacter pylori: An Evaluation in Public and Private Health Systems of Southern Chile. Pathogens 2019, 8, 226.

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