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Insects 2016, 7(4), 53;

The Differential Effect of Low-Dose Mixtures of Four Pesticides on the Pea Aphid Acyrthosiphon pisum

Laboratoire Stress Oxydant et Pathologies Métaboliques, Institut de Biologie en Santé, Université d’Angers, INSERM 1063, 49933 Angers, France
Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), Université d’Orléans, UPRES EA 1207-USC INRA, Rue de Chartres, BP 6759, 45067 Orléans, France
Author to whom correspondence should be addressed.
Academic Editor: Brian T. Forschler
Received: 13 June 2016 / Revised: 29 September 2016 / Accepted: 8 October 2016 / Published: 12 October 2016
Full-Text   |   PDF [203 KB, uploaded 12 October 2016]


The modes of action of most insecticides are known, but little information exists regarding the toxicological interactions involving insecticide mixtures at low doses. The effects of mixtures of four insecticides were investigated using LC10 values (concentration leading to 10% mortality), acetamiprid (ACE, 0.235 µg/mL), chlorpyriphos (CHL, 107.0 µg/mL), deltamethrin (DEL, 5.831 µg/mL), and fipronil (FIP, 3.775 µg/mL) on the larvae of the pea aphid, Acyrthosiphon pisum. After 24 h exposure, 6 of the 11 tested combinations, DEL/FIP, ACE/DEL, CHL/FIP, ACE/DEL/FIP, ACE/CHL/FIP, and ACE/DEL/CHL/FIP, were toxic through an additive effect. Four combinations, ACE/FIP, DEL/CHL, ACE/CHL, and ACE/DEL/CHL had a synergistic effect, whereas only one DEL/CHL/FIP showed an antagonistic effect. The toxic effect of these mixtures was confirmed after 48 h of exposure, revealing an enhanced toxicity of CHL, DEL, and FIP in combination with ACE. We suggest that an insect pest management strategy should be evaluated in the future using different combinations of insecticides. View Full-Text
Keywords: aphid; neonicotinoid; organophosphate; pyrethroid; phenylpyrazol aphid; neonicotinoid; organophosphate; pyrethroid; phenylpyrazol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Taillebois, E.; Thany, S.H. The Differential Effect of Low-Dose Mixtures of Four Pesticides on the Pea Aphid Acyrthosiphon pisum. Insects 2016, 7, 53.

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