Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. SNPs Selection and Genotyping
2.3. Statistical Analysis
3. Results
3.1. Statistical Analysis between Clinical and Demographic Data
3.2. Association Analysis between SNPs and COVID-19 Outcomes
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | COVID-19 Patients N = 225 | Neurological Symptoms 1 N = 158 | Long COVID-19 2 N = 81 | Without Complications 3 N = 67 | Controls N = 111 |
---|---|---|---|---|---|
Sex, n (%) | |||||
Women | 173 (76.9) | 119 (75.3) | 64 (79.0) | 46 (68.7) | 93 (83.8) |
Men | 52 (23.1) | 39 (24.7) | 17 (21.0) | 21 (31.3) | 18 (16.2) |
COVID-19 severity, n (%) | |||||
Mild | 185 (82.2) | 126 (79.7) | 81 (75.3) | 60 (89.6) | - |
Moderate | 40 (17.8) | 32 (20.3) | 20 (24.7) | 7 (10.4) | - |
Neurological symptoms, n (%) severe headache | - | 23 (14.6) | 0 | - | - |
memory problems | - | 3 (1.9) | 63 (77.8) | - | - |
anosmia/dysosmia | - | 147 (93.0) | 11 (13.6) | - | - |
ageusia/dysgeusia | - | 35 (22.1) | 2 (2.5) | - | - |
sleep problems | - | 5 (3.2) | 20 (24.7) | - | - |
depression | - | 5 (3.2) | 7 (8.6) | - | - |
rsID | Gene Name | EA/NEA | SARS-CoV-2 Infection | Accompanying Neurological Symptoms | Long-Term Neurological Symptoms | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
EAF Cases/Controls | β | p-Value | EAF Cases/Controls | β | p-Value | EAF Cases/Controls | β | p-Value | |||
rs114067890 | SMRR1 | G/A | 0.01/0 | <0.01 | 0.99 | 0.01/0 | 0.62 | 0.53 | 0.01/0.01 | 0.32 | 0.74 |
rs10911734 | IVNS1ABP | T/C | 0.30/0.37 | −1.41 | 0.15 | 0.31/0.34 | −0.65 | 0.51 | 0.30/0.33 | −0.57 | 0.56 |
rs2531743 | SLC6A20 | A/G | 0.50/0.44 | 1.17 | 0.24 | 0.49/0.47 | 0.47 | 0.63 | 0.55/0.46 | 1.99 | 0.045c |
rs17078348 | LZTFL1 | G/A | 0.09/0.09 | <0.01 | 0.99 | 0.10/0.09 | 0.40 | 0.68 | 0.11/0.09 | 0.55 | 0.57 |
rs9380142 | HLA-G | G/A | 0.23/0.29 | −1.30 | 0.19 | 0.21/0.28 | −1.70 | 0.09 | 0.26/0.25 | 0.25 | 0.80 |
rs112640945 | CCHCR1 | T/C | 0.15/0.16 | −0.04 | 0.96 | 0.15/0.16 | −0.48 | 0.63 | 0.14/0.16 | −0.65 | 0.51 |
rs3131294 | NOTCH4 | A/G | 0.17/0.15 | 0.36 | 0.71 | 0.17/0.15 | 0.67 | 0.49 | 0.14/0.16 | −0.52 | 0.59 |
rs657152 | ABO | A/C | 0.44/0.46 | - | - | 0.45/0.44 | - | - | 0.47/0.44 | - | - |
rs505922 | ABO | C/T | 0.39/0.42 | −0.82 | 0.40 | 0.42/0.38 | 0.82 | 0.41 | 0.42/0.39 | 0.70 | 0.48 |
rs635634 | ABO | T/C | 0.39/0.42 | - | - | 0.38/0.42 | - | - | 0.35/0.41 | - | - |
rs35705950 | MUC5B | T/G | 0.13/0.16 | −0.60 | 0.54 | 0.13/0.15 | −0.41 | 0.67 | 0.16/0.14 | 0.63 | 0.52 |
rs4766664 | OAS1 | T/G | 0.28/0.21 | 1.00 | 0.31 | 0.29/0.25 | 0.98 | 0.32 | 0.30/0.26 | 0.88 | 0.37 |
rs10735079 | OAS3 | G/A | 0.31/0.32 | −0.08 | 0.93 | 0.34/0.29 | 1.19 | 0.23 | 0.26/0.33 | −1.41 | 0.14 |
rs1894401 | FURIN | G/A | 0.50/0.39 | 2.74 | 0.006a | 0.50/0.44 | 1.52 | 0.12 | 0.49/0.46 | 0.61 | 0.54 |
rs2109069 | DPP9 | A/G | 0.21/0.20 | 0.25 | 0.79 | 0.21/0.20 | 0.18 | 0.85 | 0.23/0.20 | 0.66 | 0.50 |
rs2304256 | TYK2 | A/C | 0.13/0.18 | −1.53 | 0.12 | 0.14/0.15 | −0.42 | 0.67 | 0.17/0.14 | 0.79 | 0.42 |
rs45524632 | KEAP1 | A/C | 0.04/0.04 | −0.08 | 0.93 | 0.02/0.05 | −1.40 | 0.16 | 0.03/0.04 | −0.41 | 0.67 |
rs769449 | APOE | A/G | 0.11/0.10 | 0.26 | 0.79 | 0.12/0.09 | 0.97 | 0.32 | 0.11/0.11 | 0.03 | 0.97 |
rs7412 | APOE | T/C | 0.20/0.22 | −0.71 | 0.47 | 0.19/0.22 | −0.74 | 0.45 | 0.18/0.21 | −0.72 | 0.47 |
rs1405655 | NR1H2 | C/T | 0.43/0.37 | 1.15 | 0.24 | 0.46/0.36 | 2.37 | 0.017b | 0.42/0.41 | 0.34 | 0.73 |
rs61735789 | TMPRSS2 | A/G | 0.10/0.11 | - | - | 0.11/0.10 | - | - | 0.11/0.11 | - | - |
rs12329760 | TMPRSS2 | T/C | 0.31/0.31 | <0.01 | 0.99 | 0.30/0.31 | −0.22 | 0.81 | 0.29/0.31 | −0.52 | 0.60 |
rs4290734 | TMPRSS2 | G/A | 0.31/0.26 | 1.22 | 0.22 | 0.33/0.26 | 1.76 | 0.078 | 0.32/0.29 | 0.64 | 0.51 |
rs117696554 | TMPRSS2 | A/G | 0.19/0.18 | - | - | 0.18/0.17 | - | - | 0.15/0.18 | - | - |
rs2838046 | TMPRSS2 | G/A | 0.31/0.31 | - | - | 0.33/0.29 | - | - | 0.30/0.31 | - | - |
Predictor | Reference Group | Analyzed Group | SARS-CoV-2 Infection | Accompanying Neurological Symptoms | Long-Term Neurological Symptoms | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
β | S.E. | p-Value | β | S.E. | p-Value | β | S.E. | p-Value | |||
Sex | Men | Women | −0.58 | 0.35 | 0.099 | - | - | - | - | - | - |
FURIN rs1894401 | AA | GG+GA | 0.85 | 0.29 | 0.0038 | - | - | - | 0.58 | 0.34 | 0.088 |
SLC6A20 rs2531743 | GG | AA+AG | 0.66 | 0.29 | 0.026 | - | - | - | 0.75 | 0.34 | 0.031 |
NR1H2 rs1405655 | TT | CC | - | - | - | 1.09 | 0.39 | 0.0059 | - | - | - |
TMPRSS2 rs4290734 | AA | AG | - | - | - | 0.71 | 0.27 | 0.0099 | - | - | - |
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Kazantseva, A.; Enikeeva, R.; Takhirova, Z.; Davydova, Y.; Mustafin, R.; Malykh, S.; Karunas, A.; Kanapin, A.; Khusnutdinova, E. Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis. J. Pers. Med. 2023, 13, 123. https://doi.org/10.3390/jpm13010123
Kazantseva A, Enikeeva R, Takhirova Z, Davydova Y, Mustafin R, Malykh S, Karunas A, Kanapin A, Khusnutdinova E. Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis. Journal of Personalized Medicine. 2023; 13(1):123. https://doi.org/10.3390/jpm13010123
Chicago/Turabian StyleKazantseva, Anastasiya, Renata Enikeeva, Zalina Takhirova, Yuliya Davydova, Rustam Mustafin, Sergey Malykh, Alexandra Karunas, Alexander Kanapin, and Elza Khusnutdinova. 2023. "Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis" Journal of Personalized Medicine 13, no. 1: 123. https://doi.org/10.3390/jpm13010123