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Future Trends in Nebulized Therapies for Pulmonary Disease

1
Anaesthesia, School of Medicine, National University of Ireland Galway, H91 TK33 Galway, Ireland
2
Lung Biology Group, Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, National University of Ireland Galway, H91 TK33 Galway, Ireland
3
Physiology, School of Medicine, National University of Ireland Galway, H91 TK33 Galway, Ireland
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2020, 10(2), 37; https://doi.org/10.3390/jpm10020037
Received: 2 April 2020 / Revised: 5 May 2020 / Accepted: 7 May 2020 / Published: 10 May 2020
(This article belongs to the Special Issue The Interface between Human Physiology and Medical Device Development)
Aerosol therapy is a key modality for drug delivery to the lungs of respiratory disease patients. Aerosol therapy improves therapeutic effects by directly targeting diseased lung regions for rapid onset of action, requiring smaller doses than oral or intravenous delivery and minimizing systemic side effects. In order to optimize treatment of critically ill patients, the efficacy of aerosol therapy depends on lung morphology, breathing patterns, aerosol droplet characteristics, disease, mechanical ventilation, pharmacokinetics, and the pharmacodynamics of cell-drug interactions. While aerosol characteristics are influenced by drug formulations and device mechanisms, most other factors are reliant on individual patient variables. This has led to increased efforts towards more personalized therapeutic approaches to optimize pulmonary drug delivery and improve selection of effective drug types for individual patients. Vibrating mesh nebulizers (VMN) are the dominant device in clinical trials involving mechanical ventilation and emerging drugs. In this review, we consider the use of VMN during mechanical ventilation in intensive care units. We aim to link VMN fundamentals to applications in mechanically ventilated patients and look to the future use of VMN in emerging personalized therapeutic drugs. View Full-Text
Keywords: aerosol therapy; ARDS; COPD; intensive care unit; jet nebulizer; mechanical ventilation; sepsis; vibrating mesh nebulizer; nebulization aerosol therapy; ARDS; COPD; intensive care unit; jet nebulizer; mechanical ventilation; sepsis; vibrating mesh nebulizer; nebulization
MDPI and ACS Style

McCarthy, S.D.; González, H.E.; Higgins, B.D. Future Trends in Nebulized Therapies for Pulmonary Disease. J. Pers. Med. 2020, 10, 37.

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