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Surveillance for Hepatocellular Carcinoma in Patients with NASH

Hepatology, Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, 3010 Bern, Switzerland
Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Diagnostics 2016, 6(2), 22;
Received: 3 February 2016 / Revised: 12 April 2016 / Accepted: 31 May 2016 / Published: 7 June 2016
(This article belongs to the Special Issue Diagnosis of Hepatocellular Carcinoma)
PDF [173 KB, uploaded 7 June 2016]


European and American guidelines recommend surveillance for hepatocellular carcinoma (HCC) by performing ultrasonography on a six-month basis on an at risk population, defined by presence of cirrhosis. HCC, due to non-alcoholic steatohepatitis (NASH), is rising. Patients with NASH have a high risk of developing HCC and, therefore, have to be enrolled in a screening program. One of the challenges with NASH-induced HCC is that half of the cases arise in non-cirrhotic patients. There is a need to identify those patients in order to screen them for HCC. The obesity of these patients is another challenge, it makes ultrasound screening more difficult. Other radiological methods, such as computer tomography (CT) scans or magnetic resonance imaging (MRI), are available, but the surveillance program would no longer be cost-effective. There is a need to prospectively acquire information on cohorts of patients with NASH in order to improve the tools we have to diagnose early tumors in these patients. View Full-Text
Keywords: HCC; NASH; NAFLD; surveillance; screening HCC; NASH; NAFLD; surveillance; screening
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kolly, P.; Dufour, J.-F. Surveillance for Hepatocellular Carcinoma in Patients with NASH. Diagnostics 2016, 6, 22.

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