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Review

Hormonal Regulation of Renal Fibrosis

1
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
2
Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Marta Bueno
Life 2022, 12(5), 737; https://doi.org/10.3390/life12050737
Received: 19 April 2022 / Revised: 11 May 2022 / Accepted: 13 May 2022 / Published: 16 May 2022
(This article belongs to the Special Issue Regeneration: Biology and Medicine)
Fibrosis is a severe complication of many acute and chronic kidney pathologies. According to current concepts, an imbalance in the synthesis and degradation of the extracellular matrix by fibroblasts is considered the key cause of the induction and progression of fibrosis. Nevertheless, inflammation associated with the damage of tissue cells is among the factors promoting this pathological process. Most of the mechanisms accompanying fibrosis development are controlled by various hormones, which makes humoral regulation an attractive target for therapeutic intervention. In this vein, it is particularly interesting that the kidney is the source of many hormones, while other hormones regulate renal functions. The normal kidney physiology and pathogenesis of many kidney diseases are sex-dependent and thus modulated by sex hormones. Therefore, when choosing therapy, it is necessary to focus on the sex-associated characteristics of kidney functioning. In this review, we considered renal fibrosis from the point of view of vasoactive and reproductive hormone imbalance. The hormonal therapy possibilities for the treatment or prevention of kidney fibrosis are also discussed. View Full-Text
Keywords: fibrosis; fibroblasts; kidney; oxidative stress; water–salt balance; sex hormones fibrosis; fibroblasts; kidney; oxidative stress; water–salt balance; sex hormones
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MDPI and ACS Style

Abramicheva, P.A.; Plotnikov, E.Y. Hormonal Regulation of Renal Fibrosis. Life 2022, 12, 737. https://doi.org/10.3390/life12050737

AMA Style

Abramicheva PA, Plotnikov EY. Hormonal Regulation of Renal Fibrosis. Life. 2022; 12(5):737. https://doi.org/10.3390/life12050737

Chicago/Turabian Style

Abramicheva, Polina A., and Egor Y. Plotnikov. 2022. "Hormonal Regulation of Renal Fibrosis" Life 12, no. 5: 737. https://doi.org/10.3390/life12050737

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