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Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases

1
Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 02-093 Warsaw, Poland
2
Department of General and Experimental Pathology, Medical University of Warsaw, 02-091 Warsaw, Poland
3
Łukasiewicz Research Network-Pharmaceutical Research Institute, 01-793 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Life 2020, 10(4), 50; https://doi.org/10.3390/life10040050
Received: 31 March 2020 / Revised: 20 April 2020 / Accepted: 20 April 2020 / Published: 24 April 2020
(This article belongs to the Section Pharmaceutical Sciences)
The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an increasingly attractive drug target. It plays an indispensable role in many cellular pathways, and numerous H4R ligands are being studied for the treatment of several inflammatory, allergic, and autoimmune disorders, including pulmonary fibrosis. Activation of H4R is involved in cytokine production and mediates mast cell activation and eosinophil chemotaxis. The importance of this receptor has also been shown in inflammatory models: peritonitis, respiratory tract inflammation, colitis, osteoarthritis, and rheumatoid arthritis. Recent studies suggest that H4R acts as a modulator in cancer, neuropathic pain, vestibular disorders, and type-2 diabetes, however, its role is still not fully understood. View Full-Text
Keywords: histamine H4 receptor; G protein-coupled receptors; allergic diseases; inflammatory diseases; autoimmune disorders; neuropathic pain; cancer histamine H4 receptor; G protein-coupled receptors; allergic diseases; inflammatory diseases; autoimmune disorders; neuropathic pain; cancer
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MDPI and ACS Style

Mehta, P.; Miszta, P.; Rzodkiewicz, P.; Michalak, O.; Krzeczyński, P.; Filipek, S. Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases. Life 2020, 10, 50.

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