Biocompatible Hydrotalcite Nanohybrids for Medical Functions
1
Department of Nano Materials Science and Engineering, Kyungnam University, Changwon 51767, Gyeongsangnamdo, Korea
2
College of Chemistry and Environmental Engineering, Jiujiang University, Jiujiang 332005, Jiangxi, China
3
Department of Environmental Engineering, Yonsei University, Wonju 26493, Gangwondo, Korea
*
Authors to whom correspondence should be addressed.
Minerals 2020, 10(2), 172; https://doi.org/10.3390/min10020172
Received: 31 December 2019 / Revised: 5 February 2020 / Accepted: 6 February 2020 / Published: 14 February 2020
(This article belongs to the Special Issue Clays and Micro-Organisms: From Nature to Industry)
Biocompatible hydrotalcite nanohybrids, i.e., layered double hydroxide (LDH) based nanohybrids have attracted significant attention for biomedical functions. Benefiting from good biocompatibility, tailored drug incorporation, high drug loading capacity, targeted cellular delivery and natural pH-responsive biodegradability, hydrotalcite nanohybrids have shown great potential in drug/gene delivery, cancer therapy and bio-imaging. This review aims to summarize recent progress of hydrotalcite nanohybrids, including the history of the hydrotalcite-like compounds for application in the medical field, synthesis, functionalization, physicochemical properties, cytotoxicity, cellular uptake mechanism, as well as their related applications in biomedicine. The potential and challenges will also be discussed for further development of LDHs both as drug delivery carriers and diagnostic agents.
Keywords:
hydrotalcite; nanohybrids; layered double hydroxide; biomedical; therapy; bio-imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Jin, W.; Lee, D.; Jeon, Y.; Park, D.-H. Biocompatible Hydrotalcite Nanohybrids for Medical Functions. Minerals 2020, 10, 172.
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