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Genes, Volume 15, Issue 4

April 2024 - 134 articles

Cover Story: Polymerase chain reactions (PCRs) play a fundamental role in our understanding of the world and are widely employed. The introduction of PCRs into forensic science marked the beginning of a new era of DNA profiling. This era has pushed PCRs to their limits and allowed genetic data to be generated from even trace amounts of DNA. Trace samples contain very small amounts of degraded DNA associated with inhibitory compounds and ions. Despite significant development in the PCR technique since it was first introduced, the challenges of profiling inhibited and degraded samples remain. This review examines the evolution of the PCR from its inception in the 1980s to its current applications in forensic science and discusses the possible future directions for DNA profiling. View this paper
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Articles (134)

  • Article
  • Open Access
10 Citations
2,795 Views
28 Pages

Dissecting Selective Signatures and Candidate Genes in Grandparent Lines Subject to High Selection Pressure for Broiler Production and in a Local Russian Chicken Breed of Ushanka

  • Michael N. Romanov,
  • Alexey V. Shakhin,
  • Alexandra S. Abdelmanova,
  • Natalia A. Volkova,
  • Dmitry N. Efimov,
  • Vladimir I. Fisinin,
  • Liudmila G. Korshunova,
  • Dmitry V. Anshakov,
  • Arsen V. Dotsev and
  • Darren K. Griffin
  • + 1 author

22 April 2024

Breeding improvements and quantitative trait genetics are essential to the advancement of broiler production. The impact of artificial selection on genomic architecture and the genetic markers sought remains a key area of research. Here, we used whol...

  • Article
  • Open Access
4 Citations
2,632 Views
25 Pages

Effects of Long-Term Cryopreservation on the Transcriptomes of Giant Grouper Sperm

  • Xiaoyu Ding,
  • Yongsheng Tian,
  • Yishu Qiu,
  • Pengfei Duan,
  • Xinyi Wang,
  • Zhentong Li,
  • Linlin Li,
  • Yang Liu and
  • Linna Wang

22 April 2024

The giant grouper fish (Epinephelus lanceolatus), one of the largest and rarest groupers, is a fast-growing economic fish. Grouper sperm is often used for cross-breeding with other fish and therefore sperm cryopreservation is important. However, free...

  • Article
  • Open Access
2 Citations
1,952 Views
15 Pages

22 April 2024

Globally, SARS-CoV-2 has negatively impacted many lives and industries due to its rapid spread, severe outcomes, and the need for the implementation of lockdown strategies across the world. SARS-CoV-2 disease severity varies among different populatio...

  • Article
  • Open Access
1 Citations
2,327 Views
14 Pages

22 April 2024

The nomenclature of star alleles has been widely used in pharmacogenomics to enhance treatment outcomes, predict drug response variability, and reduce adverse reactions. However, the discovery of numerous rare functional variants through genome seque...

  • Commentary
  • Open Access
1 Citations
3,666 Views
18 Pages

21 April 2024

DNA damage causes the mutations that are the principal source of genetic variation. DNA damage detection and repair mechanisms therefore play a determining role in generating the genetic diversity on which natural selection acts. Speciation, it is co...

  • Article
  • Open Access
5 Citations
3,410 Views
21 Pages

21 April 2024

Post-traumatic stress disorder (PTSD) is the most common psychiatric disorder after a catastrophic event; however, the efficacious treatment options remain insufficient. Increasing evidence suggests that cannabidiol (CBD) exhibits optimal therapeutic...

  • Article
  • Open Access
2,493 Views
9 Pages

22q11.2 Deletion Syndrome: Influence of Parental Origin on Clinical Heterogeneity

  • Melissa Bittencourt de Wallau,
  • Ana Carolina Xavier,
  • Carolina Araújo Moreno,
  • Chong Ae Kim,
  • Elaine Lustosa Mendes,
  • Erlane Marques Ribeiro,
  • Amanda Oliveira,
  • Têmis Maria Félix,
  • Agnes Cristina Fett-Conte and
  • Luciana Cardoso Bonadia
  • + 4 authors

21 April 2024

22q11.2 deletion syndrome (22q11.2DS) shows significant clinical heterogeneity. This study aimed to explore the association between clinical heterogeneity in 22q11.2DS and the parental origin of the deletion. The parental origin of the deletion was d...

  • Article
  • Open Access
3 Citations
3,296 Views
18 Pages

Information Provision Regarding Health-Related Direct-to-Consumer Genetic Testing for Dutch Consumers: An in-Depth Content Analysis of Sellers’ Websites

  • Danny Bruins,
  • Suzanne M. Onstwedder,
  • Martina C. Cornel,
  • Margreet G. E. M. Ausems,
  • Marc H. W. van Mil and
  • Tessel Rigter

20 April 2024

Background: Previous studies have suggested that information offered by sellers of health-related direct-to-consumer genetic tests (DTC-GTs) is often incomplete, unbalanced, or too difficult to understand. The extent to which this is the case for sel...

  • Case Report
  • Open Access
5 Citations
3,638 Views
13 Pages

Syndromic Retinitis Pigmentosa: A 15-Patient Study

  • Ianne Pessoa Holanda,
  • Priscila Hae Hyun Rim,
  • Rare Genomes Project Consortium,
  • Mara Sanches Guaragna,
  • Vera Lúcia Gil-da-Silva-Lopes and
  • Carlos Eduardo Steiner

20 April 2024

Retinitis pigmentosa is a group of genetically determined retinal dystrophies characterized by primary photoreceptor apoptosis and can occur in isolated or syndromic conditions. This study reviewed the clinical data of 15 patients with syndromic reti...

  • Article
  • Open Access
2 Citations
2,040 Views
10 Pages

Identification of Crucial Modules and Genes Associated with Bt Gene Expression in Cotton

  • Guiyuan Zhao,
  • Zhao Geng,
  • Jianguang Liu,
  • Haiyan Tian,
  • Xu Liu,
  • Zetong An,
  • Ning Zhao,
  • Hanshuang Zhang,
  • Liqiang Wu and
  • Xingfen Wang
  • + 2 authors

19 April 2024

The expression of Bacillus thuringiensis (Bt) toxins in transgenic cotton confers resistance to insect pests. However, it has been demonstrated that its effectiveness varies among cotton cultivars and different tissues. In this study, we evaluated th...

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Genes - ISSN 2073-4425