Genetic Distribution of Five Spinocerebellar Ataxia Microsatellite Loci in Mexican Native American Populations and Its Impact on Contemporary Mestizo Populations
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Molecular Genetic Analysis
2.3. Statistical Analyses
2.4. Comparative Data
3. Results
3.1. Allele Frequencies and Genetic Diversity of Five SCA Loci in Mexican Native American Populations
3.2. Absence of SCA Pathological Alleles in Mexican Native Americans Populations
3.3. Genetic Interplay between Mexican Native American Populations
3.4. Comparison of the SCA Loci Allelic Distribution between Mexican Native American and Worldwide Populations
4. Discussion
4.1. Searching for Large SCA Alleles in Mexican Native Americans
4.2. Genetic Landscape of Mexican Native American Populations Using SCA Microsatellite Loci
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Source of Variation | Variation (%) | p-Value |
---|---|---|
Global | ||
Among populations | 3.29 | 0.004 |
Among individuals within population | 52.43 | ≤0.0001 |
Within individuals | 44.27 | ≤0.0001 |
Geography | ||
Among populations | 4.02 | 0.0001 |
Among individuals within population | 52.04 | ≤0.0001 |
Within individuals | 43.94 | ≤0.0001 |
Language | ||
Among populations | 3.99 | ≤0.0001 |
Among individuals within population | 51.98 | ≤0.0001 |
Within individuals | 44.03 | ≤0.0001 |
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Gómez, R.; Tapia-Guerrero, Y.S.; Cisneros, B.; Orozco, L.; Cerecedo-Zapata, C.; Mendoza-Caamal, E.; Leyva-Gómez, G.; Leyva-García, N.; Velázquez-Pérez, L.; Magaña, J.J. Genetic Distribution of Five Spinocerebellar Ataxia Microsatellite Loci in Mexican Native American Populations and Its Impact on Contemporary Mestizo Populations. Genes 2022, 13, 157. https://doi.org/10.3390/genes13010157
Gómez R, Tapia-Guerrero YS, Cisneros B, Orozco L, Cerecedo-Zapata C, Mendoza-Caamal E, Leyva-Gómez G, Leyva-García N, Velázquez-Pérez L, Magaña JJ. Genetic Distribution of Five Spinocerebellar Ataxia Microsatellite Loci in Mexican Native American Populations and Its Impact on Contemporary Mestizo Populations. Genes. 2022; 13(1):157. https://doi.org/10.3390/genes13010157
Chicago/Turabian StyleGómez, Rocío, Yessica S. Tapia-Guerrero, Bulmaro Cisneros, Lorena Orozco, César Cerecedo-Zapata, Elvia Mendoza-Caamal, Gerardo Leyva-Gómez, Norberto Leyva-García, Luis Velázquez-Pérez, and Jonathan J. Magaña. 2022. "Genetic Distribution of Five Spinocerebellar Ataxia Microsatellite Loci in Mexican Native American Populations and Its Impact on Contemporary Mestizo Populations" Genes 13, no. 1: 157. https://doi.org/10.3390/genes13010157
APA StyleGómez, R., Tapia-Guerrero, Y. S., Cisneros, B., Orozco, L., Cerecedo-Zapata, C., Mendoza-Caamal, E., Leyva-Gómez, G., Leyva-García, N., Velázquez-Pérez, L., & Magaña, J. J. (2022). Genetic Distribution of Five Spinocerebellar Ataxia Microsatellite Loci in Mexican Native American Populations and Its Impact on Contemporary Mestizo Populations. Genes, 13(1), 157. https://doi.org/10.3390/genes13010157