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Orphan G Protein Coupled Receptors in Affective Disorders

Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
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Genes 2020, 11(6), 694; https://doi.org/10.3390/genes11060694
Received: 3 June 2020 / Revised: 20 June 2020 / Accepted: 21 June 2020 / Published: 24 June 2020
(This article belongs to the Special Issue Genes and Biomarkers of Mood and Anxiety Disorders)
G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antidepressant therapies. Importantly, the endogenous ligands for a large group of GPCRs have not yet been identified and are therefore known as orphan GPCRs (oGPCRs). Nonetheless, growing evidence from animal studies, together with genome wide association studies (GWAS) and post-mortem transcriptomic analysis in patients, pointed at many oGPCRs as potential pharmacological targets. Among these discoveries, we summarize in this review how emotional behaviors are modulated by the following oGPCRs: ADGRB2 (BAI2), ADGRG1 (GPR56), GPR3, GPR26, GPR37, GPR50, GPR52, GPR61, GPR62, GPR88, GPR135, GPR158, and GPRC5B. View Full-Text
Keywords: G protein coupled receptor (GPCR); G proteins; orphan GPCR (oGPCR); mood disorders; major depressive disorder (MDD); bipolar disorder (BPD); anxiety disorders; antidepressant; animal models G protein coupled receptor (GPCR); G proteins; orphan GPCR (oGPCR); mood disorders; major depressive disorder (MDD); bipolar disorder (BPD); anxiety disorders; antidepressant; animal models
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Watkins, L.R.; Orlandi, C. Orphan G Protein Coupled Receptors in Affective Disorders. Genes 2020, 11, 694.

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