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Article

Transcriptional Differences of Coding and Non-Coding Genes Related to the Absence of Melanocyte in Skins of Bama Pig

1
Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
2
College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
3
Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2020, 11(1), 47; https://doi.org/10.3390/genes11010047
Received: 4 November 2019 / Revised: 16 December 2019 / Accepted: 22 December 2019 / Published: 30 December 2019
(This article belongs to the Section Animal Genetics and Genomics)
Skin is the body’s largest organ, and the main function of skin is to protect underlying organs from possible external damage. Melanocytes play an important role in skin pigmentation. The Bama pig has a “two-end-black” phenotype with different coat colors across skin regions, e.g., white skin (without melanocytes) and black skin (with melanocytes), which could be a model to investigate skin-related disorders, specifically loss of melanocytes. Here, we generated expression profiles of mRNAs and long noncoding RNAs in Bama pig skins with different coat colors. In total, 14,900 mRNAs and 7549 lncRNAs were expressed. Overall, 2338 mRNAs/113 lncRNAs with FDR-adjusted p-value ≤ 0.05 were considered to be differentially expressed (DE) mRNAs/lncRNAs, with 1305 down-regulated mRNAs and 1033 up-regulated mRNAs in white skin with|log2(fold change)| > 1. The genes down-regulated in white skin were associated with pigmentation, melanocyte–keratinocyte interaction, and keratin, while up-regulated ones were mainly associated with cellular energy metabolisms. Furthermore, those DE lncRNAs were predicted to be implicated in pigmentation, keratin synthesis and cellular energy metabolism. In general, this study provides insight into the transcriptional difference involved in melanocyte-loss-induced keratinocyte changes and promotes the Bama pig as a biomedical model in skin research. View Full-Text
Keywords: melanocyte deficiency; Bama pig; model; transcriptome melanocyte deficiency; Bama pig; model; transcriptome
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MDPI and ACS Style

Jin, L.; Zhao, L.; Hu, S.; Long, K.; Liu, P.; Liu, R.; Zhou, X.; Wang, Y.; Huang, Z.; Lin, X.; Tang, Q.; Li, M. Transcriptional Differences of Coding and Non-Coding Genes Related to the Absence of Melanocyte in Skins of Bama Pig. Genes 2020, 11, 47. https://doi.org/10.3390/genes11010047

AMA Style

Jin L, Zhao L, Hu S, Long K, Liu P, Liu R, Zhou X, Wang Y, Huang Z, Lin X, Tang Q, Li M. Transcriptional Differences of Coding and Non-Coding Genes Related to the Absence of Melanocyte in Skins of Bama Pig. Genes. 2020; 11(1):47. https://doi.org/10.3390/genes11010047

Chicago/Turabian Style

Jin, Long, Lirui Zhao, Silu Hu, Keren Long, Pengliang Liu, Rui Liu, Xuan Zhou, Yixin Wang, Zhiqing Huang, Xuxu Lin, Qianzi Tang, and Mingzhou Li. 2020. "Transcriptional Differences of Coding and Non-Coding Genes Related to the Absence of Melanocyte in Skins of Bama Pig" Genes 11, no. 1: 47. https://doi.org/10.3390/genes11010047

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