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Volatile Evolution of Long Non-Coding RNA Repertoire in Retinal Pigment Epithelium: Insights from Comparison of Bovine and Human RNA Expression Profiles

Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894, USA
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Laboratory of Neuropathology Modeling, The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia
Author to whom correspondence should be addressed.
Genes 2019, 10(3), 205;
Received: 31 January 2019 / Revised: 22 February 2019 / Accepted: 26 February 2019 / Published: 8 March 2019
(This article belongs to the Section Population and Evolutionary Genetics and Genomics)
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Currently, several long non-coding RNAs (lncRNAs) (TUG1, MALAT1, MEG3 and others) have been discovered to regulate normal visual function and may potentially contribute to dysfunction of the retina. We decided to extend these analyses of lncRNA genes to the retinal pigment epithelium (RPE) to determine whether there is conservation of RPE-expressed lncRNA between human and bovine genomes. We reconstructed bovine RPE lncRNAs based on genome-guided assembly. Next, we predicted homologous human transcripts based on whole genome alignment. We found a small set of conserved lncRNAs that could be involved in signature RPE functions that are conserved across mammals. However, the fraction of conserved lncRNAs in the overall pool of lncRNA found in RPE appeared to be very small (less than 5%), perhaps reflecting a fast and flexible adaptation of the mammalian eye to various environmental conditions. View Full-Text
Keywords: lncRNA; RPE; evolutionary conservation; bovine lncRNA lncRNA; RPE; evolutionary conservation; bovine lncRNA

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Postnikova, O.A.; Rogozin, I.B.; Samuel, W.; Nudelman, G.; Babenko, V.N.; Poliakov, E.; Redmond, T.M. Volatile Evolution of Long Non-Coding RNA Repertoire in Retinal Pigment Epithelium: Insights from Comparison of Bovine and Human RNA Expression Profiles. Genes 2019, 10, 205.

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