Table of Contents
Genes, Volume 10, Issue 2 (February 2019)
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Cover Story (view full-size image) Observations of chemo/radio-resistant cells undergoing reversible polyploidy presented in this [...] Read more. Observations of chemo/radio-resistant cells undergoing reversible polyploidy presented in this issue by Salmina et al. in the article “The cancer aneuploidy paradox: In the light of evolution” address this paradox. Through a dysfunctional spindle, cancer stem cells segregate parental groups of end-to-end linked dyads originating tetraploid cells. This is followed by autokaryogamy, pairing and recombination at centromeres in the octoploid endo-prophase. The process is completed by reduction divisions and release of secondary cells. It shares features with asexual ploidy cycles seen earlier in evolution, facilitating a reduction in the mutational load of aneuploidy. The image shows a polyploid endometaphase of a lymphoma cell on day 7 post 10 Gy irradiation which displays 16 chromosomes #18 as revealed by tri-colour FISH (short arm, green; centre red; long arm terminus blue). View this paper.