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Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair

1
Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark
2
Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, DK-5230 Odense, Denmark
3
Membrane Integrity, Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark
4
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(4), 1029; https://doi.org/10.3390/cells9041029
Received: 2 April 2020 / Revised: 16 April 2020 / Accepted: 19 April 2020 / Published: 21 April 2020
(This article belongs to the Special Issue Recent Developments in Annexin Biology)
The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma membrane. To counteract plasma membrane injuries, eukaryotic cells have developed efficient repair tools that depend on Ca2+- and phospholipid-binding annexin proteins. Upon membrane damage, annexin family members are activated by a Ca2+ influx, enabling them to quickly bind at the damaged membrane and facilitate wound healing. Our recent studies, based on interdisciplinary research synergy across molecular cell biology, experimental membrane physics, and computational simulations show that annexins have additional biophysical functions in the repair response besides enabling membrane fusion. Annexins possess different membrane-shaping properties, allowing for a tailored response that involves rapid bending, constriction, and fusion of membrane edges for resealing. Moreover, some annexins have high affinity for highly curved membranes that appear at free edges near rupture sites, a property that might accelerate their recruitment for rapid repair. Here, we discuss the mechanisms of annexin-mediated membrane shaping and curvature sensing in the light of our interdisciplinary approach to study plasma membrane repair. View Full-Text
Keywords: annexin; plasma membrane repair; membrane curvature; membrane curvature sensing; membrane shaping; interdisciplinary research; cell rupture; membrane damage annexin; plasma membrane repair; membrane curvature; membrane curvature sensing; membrane shaping; interdisciplinary research; cell rupture; membrane damage
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MDPI and ACS Style

Bendix, P.M.; Simonsen, A.C.; Florentsen, C.D.; Häger, S.C.; Mularski, A.; Zanjani, A.A.H.; Moreno-Pescador, G.; Klenow, M.B.; Sønder, S.L.; Danielsen, H.M.; Arastoo, M.R.; Heitmann, A.S.; Pandey, M.P.; Lund, F.W.; Dias, C.; Khandelia, H.; Nylandsted, J. Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair. Cells 2020, 9, 1029. https://doi.org/10.3390/cells9041029

AMA Style

Bendix PM, Simonsen AC, Florentsen CD, Häger SC, Mularski A, Zanjani AAH, Moreno-Pescador G, Klenow MB, Sønder SL, Danielsen HM, Arastoo MR, Heitmann AS, Pandey MP, Lund FW, Dias C, Khandelia H, Nylandsted J. Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair. Cells. 2020; 9(4):1029. https://doi.org/10.3390/cells9041029

Chicago/Turabian Style

Bendix, Poul M., Adam C. Simonsen, Christoffer D. Florentsen, Swantje C. Häger, Anna Mularski, Ali A.H. Zanjani, Guillermo Moreno-Pescador, Martin B. Klenow, Stine L. Sønder, Helena M. Danielsen, Mohammad R. Arastoo, Anne S. Heitmann, Mayank P. Pandey, Frederik W. Lund, Catarina Dias, Himanshu Khandelia, and Jesper Nylandsted. 2020. "Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair" Cells 9, no. 4: 1029. https://doi.org/10.3390/cells9041029

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