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Open AccessArticle

Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification

1
Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50610, Korea
2
Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea
3
Department of Oral and Maxillofacial Radiology, School of Dentistry, Pusan National University, Dental Research Institute, Yangsan 50610, Korea
4
Department of Dental Pharmacology, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50610, Korea
*
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 737; https://doi.org/10.3390/cells9030737
Received: 29 January 2020 / Revised: 9 March 2020 / Accepted: 13 March 2020 / Published: 17 March 2020
(This article belongs to the Special Issue Cells in Cardiovascular Disease)
Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality. Here, we investigated the role of gastrin-releasing peptide (GRP) in phosphate-induced vascular calcification and its potential regulatory mechanism. We found that the silencing of GRP gene and treatment with the GRP receptor antagonist, RC-3095, attenuated the inorganic phosphate-induced calcification of vascular smooth muscle cells (VSMCs). This attenuation was caused by inhibiting phenotype change, apoptosis and matrix vesicle release in VSMCs. Moreover, the treatment with RC-3095 effectively ameliorated phosphate-induced calcium deposition in rat aortas ex vivo and aortas of chronic kidney disease in mice in vivo. Therefore, the regulation of the GRP-GRP receptor axis may be a potential strategy for treatment of diseases associated with excessive vascular calcification. View Full-Text
Keywords: gastrin-releasing peptide; gastrin-releasing peptide receptor; vascular smooth muscle cells; vascular calcification gastrin-releasing peptide; gastrin-releasing peptide receptor; vascular smooth muscle cells; vascular calcification
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MDPI and ACS Style

Park, H.-J.; Kim, Y.; Kim, M.-K.; Hwang, J.J.; Kim, H.J.; Bae, S.-K.; Bae, M.-K. Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification. Cells 2020, 9, 737.

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