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Open AccessReview

Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development

1
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
2
Center on Human Development and Disability, University of Washington, Seattle, WA 98195, USA
3
Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge CB2 1TN, UK
*
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 733; https://doi.org/10.3390/cells9030733
Received: 24 February 2020 / Revised: 11 March 2020 / Accepted: 12 March 2020 / Published: 17 March 2020
(This article belongs to the Section Cellular Pathology)
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease. View Full-Text
Keywords: intrinsic heart rate variability; iHRV; fetal programming; cardiac development; sinus node intrinsic heart rate variability; iHRV; fetal programming; cardiac development; sinus node
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MDPI and ACS Style

Frasch, M.G.; Giussani, D.A. Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development. Cells 2020, 9, 733.

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