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In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy
Open AccessArticle

Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy

Medical Imaging Physics and Radiation Safety, Department of Radiology and Imaging Sciences, University of Utah Health, Salt Lake City, UT 84132, USA
Department of Radiation Oncology, University of Washington, Seattle, WA 98115, USA
International Atomic Energy Agency (IAEA), 1020 Wien, Austria
Author to whom correspondence should be addressed.
Cells 2020, 9(10), 2302;
Received: 30 July 2020 / Revised: 23 September 2020 / Accepted: 14 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Biology of Boron Neutron Capture Therapy (BNCT))
Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels. In this paper, we present a computational, multiscale system of models to better assess the relative biological effectiveness (RBE) and compound biological effectiveness (CBE) of several neutron sources as applied to BNCT using boronophenylalanine (BPA) and a potential monoclonal antibody (mAb) that targets HER-2-positive cells with Trastuzumab. The multiscale model is tested against published in vitro and in vivo measurements of cell survival with and without boron. The combined dosimetric and radiobiological model includes an analytical formulation that accounts for the type of neutron source, the tissue- or cancer-specific dose–response characteristics, and the microdistribution of boron. Tests of the model against results from published experiments with and without boron show good agreement between modeled and experimentally determined cell survival for neutrons alone and in combination with boron. The system of models developed in this work is potentially useful as an aid for the optimization and individualization of BNCT for HER-2-positive cancers, as well as other cancers, that can be targeted with mAb or a conventional BPA compound. View Full-Text
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MDPI and ACS Style

Streitmatter, S.W.; Stewart, R.D.; Moffitt, G.; Jevremovic, T. Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy. Cells 2020, 9, 2302.

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