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Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
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Cells 2020, 9(1), 150; https://doi.org/10.3390/cells9010150
Received: 19 December 2019 / Revised: 3 January 2020 / Accepted: 5 January 2020 / Published: 8 January 2020
(This article belongs to the Special Issue Mitochondrial Dynamics: Fusion and Fission)
Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. Mitochondria are the main cellular energy powerhouses, supplying most of ATP by oxidative phosphorylation, which is required to fuel essential neuronal functions. Efficient removal of aged and dysfunctional mitochondria through mitophagy, a cargo-selective autophagy, is crucial for mitochondrial maintenance and neuronal health. Mechanistic studies into mitophagy have highlighted an integrated and elaborate cellular network that can regulate mitochondrial turnover. In this review, we provide an updated overview of the recent discoveries and advancements on the mitophagy pathways and discuss the molecular mechanisms underlying mitophagy defects in Alzheimer’s disease and other age-related neurodegenerative diseases, as well as the therapeutic potential of mitophagy-enhancing strategies to combat these disorders. View Full-Text
Keywords: mitophagy; mitophagosome; lysosome; mitochondrial dynamics; mitochondrial quality control; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; amyotrophic lateral sclerosis; aging mitophagy; mitophagosome; lysosome; mitochondrial dynamics; mitochondrial quality control; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; amyotrophic lateral sclerosis; aging
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Cai, Q.; Jeong, Y.Y. Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases. Cells 2020, 9, 150.

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