Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease
by
Mathias Cobbaut 1,†, Simge Karagil 2,†, Lucrezia Bruno 2,3,†, Maria Del Carmen Diaz de la Loza 4, Francesca E Mackenzie 3, Michael Stolinski 2 and Ahmed Elbediwy 2,*
Mathias Cobbaut 1,†, Simge Karagil 2,†, Lucrezia Bruno 2,3,†, Maria Del Carmen Diaz de la Loza 4, Francesca E Mackenzie 3, Michael Stolinski 2 and Ahmed Elbediwy 2,*
1
Protein Phosphorylation Lab, Francis Crick Institute, London NW1 1AT, UK
2
Department of Biomolecular Sciences, Kingston University, Kingston-upon-Thames KT1 2EE, UK
3
Department of Chemical and Pharmaceutical Sciences, Kingston University, Kingston-upon-Thames KT1 2EE, UK
4
Epithelial Biology Lab, Francis Crick Institute, London NW1 1AT, UK
*
Author to whom correspondence should be addressed.
†
These authors contribute equally to this work.
Cells 2020, 9(1), 151; https://doi.org/10.3390/cells9010151
Received: 30 November 2019 / Revised: 2 January 2020 / Accepted: 4 January 2020 / Published: 8 January 2020
(This article belongs to the Special Issue Mechanotransduction in Control of Cell Fate and Function)
In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces. These mechanical forces, as experienced by cells and tissues, are then converted into biochemical signals within the cell, leading to a number of cellular mechanisms being activated, including proliferation, differentiation and migration. If the conversion of mechanical cues into biochemical signals is perturbed in any way, then this can be potentially implicated in chronic disease development and processes such as neurological disorders, cancer and obesity. This review will focus on how the interplay between mechanotransduction, cellular structure, metabolism and signalling cascades led by the Hippo-YAP/TAZ axis can lead to a number of chronic diseases and suggest how we can target various pathways in order to design therapeutic targets for these debilitating diseases and conditions.
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Keywords:
Hippo; YAP; TAZ; polarity; cancer; mechanotransduction; obesity; aPKC; neurodegenerative disease; talin; integrins
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MDPI and ACS Style
Cobbaut, M.; Karagil, S.; Bruno, L.; Diaz de la Loza, M.D.C.; Mackenzie, F.E.; Stolinski, M.; Elbediwy, A. Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease. Cells 2020, 9, 151.
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