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Cells 2019, 8(2), 108; https://doi.org/10.3390/cells8020108

Multidisciplinary Roles of LRRFIP1/GCF2 in Human Biological Systems and Diseases

Institute for Genetic Medicine, Hokkaido University, Hokkaido 060-0815, Japan
Received: 7 December 2018 / Revised: 21 January 2019 / Accepted: 27 January 2019 / Published: 31 January 2019
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Abstract

Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double stranded RNA (dsRNA)-binding protein to trans-activation responsive region (TAR) RNA of Human Immunodeficiency Virus-1 (HIV-1), termed as TAR RNA interacting protein (TRIP), and as a binding protein to the Leucine Rich Repeat (LRR) of Flightless-1(Fli-1), termed as Flightless-1 LRR associated protein 1 (FLAP1) and LRR domain of Flightless-1 interacting Protein 1 (LRRFIP1). Subsequent functional studies have revealed that LRRFIP1/GCF2 played multiple roles in the regulation of diverse biological systems and processes, such as in immune response to microorganisms and auto-immunity, remodeling of cytoskeletal system, signal transduction pathways, and transcriptional regulations of genes. Dysregulations of LRRFIP1/GCF2 have been implicated in the causes of several experimental and clinico-pathological states and the responses to them, such as autoimmune diseases, excitotoxicity after stroke, thrombosis formation, inflammation and obesity, the wound healing process, and in cancers. LRRFIP1/GCF2 is a bioregulator in multidisciplinary systems of the human body and its dysregulation can cause diverse human diseases. View Full-Text
Keywords: LRRFIP1/GCF2; transcriptional repression; nucleic acid binding; cytoskeletal system; signal transduction; cancer LRRFIP1/GCF2; transcriptional repression; nucleic acid binding; cytoskeletal system; signal transduction; cancer
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Takimoto, M. Multidisciplinary Roles of LRRFIP1/GCF2 in Human Biological Systems and Diseases. Cells 2019, 8, 108.

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