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Cells 2018, 7(10), 146;

Control of DNA Replication Initiation by Ubiquitin

Unidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, 38320 La Laguna, Tenerife, Spain
Division of Oncogenomics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Author to whom correspondence should be addressed.
Received: 5 September 2018 / Revised: 18 September 2018 / Accepted: 19 September 2018 / Published: 20 September 2018
(This article belongs to the Special Issue Ubiquitination in Health and Disease)
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Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by numerous pathways. A key step in this process is the initiation of DNA replication in which certain regions of DNA are marked as competent to replicate. Moreover, initiation of DNA replication needs to be coordinated with other cell cycle processes. At the molecular level, initiation of DNA replication relies, among other mechanisms, upon post-translational modifications, including the conjugation and hydrolysis of ubiquitin. An example is the precise control of the levels of the DNA replication initiation protein Cdt1 and its inhibitor Geminin by ubiquitin-mediated proteasomal degradation. This control ensures that DNA replication occurs with the right timing during the cell cycle, thereby avoiding re-replication events. Here, we review the events that involve ubiquitin signalling during DNA replication initiation, and how they are linked to human disease. View Full-Text
Keywords: ubiquitin; DNA replication Initiation; ubiquitin ligases; ubiquitin hydrolases; proteasome ubiquitin; DNA replication Initiation; ubiquitin ligases; ubiquitin hydrolases; proteasome

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Hernández-Carralero, E.; Cabrera, E.; Alonso-de Vega, I.; Hernández-Pérez, S.; Smits, V.A.J.; Freire, R. Control of DNA Replication Initiation by Ubiquitin. Cells 2018, 7, 146.

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