Cells, Volume 6, Issue 1 (March 2017) – 8 articles
Cover Story (view full-size image): Invariant chain trimers on B-lymphocytes are often associated with less than par amounts of MHC II and, therefore, provide binding sites for the cytokine MIF. Under sub-saturation conditions, trimeric MIF is expected to engage other invariant chain-MHC II complexes, resulting in clustering and membrane raft formation. Antigen-clustered B-cell receptors form similar membrane rafts that coalesce with rafts containing MIF-invariant chain-MHC II. This coalescence fosters signaling and co-endocytosis, and thus may strengthen B-cell receptor-guided antigen presentation. View this paper
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