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Cells 2014, 3(3), 899-913; https://doi.org/10.3390/cells3030899

Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury

1
Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Korea
2
Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City 404-834, Korea
*
Author to whom correspondence should be addressed.
Received: 26 May 2014 / Revised: 2 September 2014 / Accepted: 3 September 2014 / Published: 11 September 2014
(This article belongs to the Special Issue MicroRNAs in Cardiovascular Biology and Disease)
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Abstract

Cardiac Ca2+ cycling and signaling are closely associated with cardiac function. Changes in cellular Ca2+ homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca2+-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca2+ homeostasis and signaling and miRNA, Ca2+-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca2+ in cardiac function, as well as changes in Ca2+ cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury. View Full-Text
Keywords: microRNA; calcium; Ca2+; myocardial ischemia-reperfusion injury; heart microRNA; calcium; Ca2+; myocardial ischemia-reperfusion injury; heart
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Choi, E.; Cha, M.-J.; Hwang, K.-C. Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury. Cells 2014, 3, 899-913.

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