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TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision

by Daniel A. Ryskamp 1,2,*,†, Sarah Redmon 1,2,†, Andrew O. Jo 1,† and David Križaj 1,2,3,4,*
1
Department of Ophthalmology & Visual Sciences, Moran Eye Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
2
Interdepartmental Program in Neuroscience, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
3
Department of Neurobiology & Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
4
Center for Translational Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
*
Authors to whom correspondence should be addressed.
Those authors contributed equally to this work.
Cells 2014, 3(3), 914-938; https://doi.org/10.3390/cells3030914
Received: 1 July 2014 / Revised: 27 August 2014 / Accepted: 5 September 2014 / Published: 12 September 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the modulation of blood flow and osmoregulation but also neurotransmission, postsynaptic neuronal excitability and synaptic plasticity within the central nervous system. In addition to its central role in nociception, evidence is accumulating that TRPV1 contributes to stimulus transduction and/or processing in other sensory modalities, including thermosensation, mechanotransduction and vision. For example, TRPV1, in conjunction with intrinsic cannabinoid signaling, might contribute to retinal ganglion cell (RGC) axonal transport and excitability, cytokine release from microglial cells and regulation of retinal vasculature. While excessive TRPV1 activity was proposed to induce RGC excitotoxicity, physiological TRPV1 activity might serve a neuroprotective function within the complex context of retinal endocannabinoid signaling. In this review we evaluate the current evidence for localization and function of TRPV1 channels within the mammalian retina and explore the potential interaction of this intriguing nociceptor with endogenous agonists and modulators. View Full-Text
Keywords: retinal ganglion cells; TRPV1 channels; endocannabinoids; CB1 receptors retinal ganglion cells; TRPV1 channels; endocannabinoids; CB1 receptors
MDPI and ACS Style

Ryskamp, D.A.; Redmon, S.; Jo, A.O.; Križaj, D. TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision. Cells 2014, 3, 914-938.

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