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mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration

RNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA
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Cells 2021, 10(1), 187; https://doi.org/10.3390/cells10010187
Received: 4 December 2020 / Revised: 11 January 2021 / Accepted: 16 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue Stem Cell-Immune Function and Cardiac Regeneration)
mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration. View Full-Text
Keywords: RNA therapeutics; cell therapy; cardiovascular regeneration; inflammatory signaling; nuclear reprogramming; iPSCs; transdifferentiation; cardiovascular ageing RNA therapeutics; cell therapy; cardiovascular regeneration; inflammatory signaling; nuclear reprogramming; iPSCs; transdifferentiation; cardiovascular ageing
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MDPI and ACS Style

Chanda, P.K.; Sukhovershin, R.; Cooke, J.P. mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration. Cells 2021, 10, 187. https://doi.org/10.3390/cells10010187

AMA Style

Chanda PK, Sukhovershin R, Cooke JP. mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration. Cells. 2021; 10(1):187. https://doi.org/10.3390/cells10010187

Chicago/Turabian Style

Chanda, Palas K.; Sukhovershin, Roman; Cooke, John P. 2021. "mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration" Cells 10, no. 1: 187. https://doi.org/10.3390/cells10010187

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