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Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane

Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Author to whom correspondence should be addressed.
Academic Editor: Kell Mortensen
Polymers 2015, 7(2), 281-297;
Received: 27 November 2014 / Accepted: 3 February 2015 / Published: 11 February 2015
(This article belongs to the Collection Polysaccharides)
The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellular functions for tissue engineering. We have developed laminin-derived active peptide-chitosan matrices as functional scaffolds. The biological activity of the peptides was enhanced when the peptides were conjugated to a chitosan matrix, suggesting that the peptide-chitosan matrix approach has an advantage for an active biomaterial. Further, the laminin peptide-chitosan matrices have the potential to mimic the basement membrane and are useful for tissue engineering as an artificial basement membrane. View Full-Text
Keywords: basement membrane; laminin; peptides; polysaccharide basement membrane; laminin; peptides; polysaccharide
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Hozumi, K.; Kumai, J.; Yamada, Y.; Nomizu, M. Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane. Polymers 2015, 7, 281-297.

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