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Article

Solubilization of Paclitaxel by Self-Assembled Amphiphilic Phospholipid-Mimetic Polymers with Varied Hydrophobicity

Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Stanislaw Slomkowski
Polymers 2021, 13(16), 2805; https://doi.org/10.3390/polym13162805
Received: 29 July 2021 / Revised: 12 August 2021 / Accepted: 18 August 2021 / Published: 20 August 2021
(This article belongs to the Special Issue Polymers and Drug Delivery)
2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers have been used as a coating agent on medical devices and as a carrier in drug delivery systems (DDSs). Paclitaxel (PTX) is a water-insoluble anticancer drug whose solubilizer is necessary for administration. Block and random copolymers composed of hydrophilic MPC and butyl methacrylate, named PMB, show different properties, depending on the polymer sequence and MPC content. In the present study, we used amphiphilic MPC polymers comprising hydrophobic dodecyl methacrylate (DMA). The self-assembling properties and PTX solubilization of random and block poly(MPC-co-DMA)s (rPMDs and bPMDs) with different compositions were examined and compared. rPMDs with high DMA content formed large and relatively loose self-assembled structures, which solubilized PTX. However, bPMDs formed small and compact self-assembled structures with poor PTX solubilization. PTX solubilized by PMB with small and loose self-assembled structures showed efficient drug action, similar to free PTX; however, rPMDs fell short of demonstrating PTX efficiency. Our results suggest that the self-assembling properties and the hydrophobicity of amphiphilic MPC polymers largely affect PTX solubilization as well as drug action, which is required to be controlled by the polymer sequence, as well as the structure and composition of the hydrophobic monomer for efficient DDS. View Full-Text
Keywords: MPC polymer; hydrophobicity; polymer sequence; anticancer drug; solubilization; drug delivery MPC polymer; hydrophobicity; polymer sequence; anticancer drug; solubilization; drug delivery
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MDPI and ACS Style

Kojima, C.; Hirose, T.; Katayama, R.; Matsumoto, A. Solubilization of Paclitaxel by Self-Assembled Amphiphilic Phospholipid-Mimetic Polymers with Varied Hydrophobicity. Polymers 2021, 13, 2805. https://doi.org/10.3390/polym13162805

AMA Style

Kojima C, Hirose T, Katayama R, Matsumoto A. Solubilization of Paclitaxel by Self-Assembled Amphiphilic Phospholipid-Mimetic Polymers with Varied Hydrophobicity. Polymers. 2021; 13(16):2805. https://doi.org/10.3390/polym13162805

Chicago/Turabian Style

Kojima, Chie, Tomoka Hirose, Risa Katayama, and Akikazu Matsumoto. 2021. "Solubilization of Paclitaxel by Self-Assembled Amphiphilic Phospholipid-Mimetic Polymers with Varied Hydrophobicity" Polymers 13, no. 16: 2805. https://doi.org/10.3390/polym13162805

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