Next Article in Journal
Application of Electrospun Nanofibers for Fabrication of Versatile and Highly Efficient Electrochemical Devices: A Review
Next Article in Special Issue
Calcium-Silicate-Incorporated Gellan-Chitosan Induced Osteogenic Differentiation in Mesenchymal Stromal Cells
Previous Article in Journal
Two Fascinating Polysaccharides: Chitosan and Starch. Some Prominent Characterizations for Applying as Eco-Friendly Food Packaging and Pollutant Remover in Aqueous Medium. Progress in Recent Years: A Review
Previous Article in Special Issue
Endochondral Ossification Induced by Cell Transplantation of Endothelial Cells and Bone Marrow Stromal Cells with Copolymer Scaffold Using a Rat Calvarial Defect Model
 
 
Article

The Development of Polylactic Acid/Multi-Wall Carbon Nanotubes/Polyethylene Glycol Scaffolds for Bone Tissue Regeneration Application

by 1,2,†, 3,†, 2,4,5,* and 3,*
1
Department of Urology, Cathay General Hospital, Taipei 10603, Taiwan
2
School of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan
3
Department of Chemical and Materials Engineering, National Central University, Zhongli District, Taoyuan City 32001, Taiwan
4
Proteomics Laboratory, Department of Medical Research, Cathay General Hospital, Taipei 10630, Taiwan
5
Department of Biomedical Sciences and Engineering, National Central University, Zhongli District, Taoyuan City 32001, Taiwan
*
Authors to whom correspondence should be addressed.
These two authors contributed equally.
Academic Editor: Xiao Hu
Polymers 2021, 13(11), 1740; https://doi.org/10.3390/polym13111740
Received: 30 April 2021 / Revised: 22 May 2021 / Accepted: 23 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Polymeric Materials for Bone Tissue Engineering)
Composite electrospun fibers were fabricated to develop drug loaded scaffolds to promote bone tissue regeneration. Multi-wall carbon nanotubes (MWCNTs) were incorporated to polylactic acid (PLA) to strengthen electrospun nanofibers. To modulate drug release behavior, different ratios of hydrophilic polyethylene glycol (PEG) were added to composite fibers. Glass transition temperature (Tg) can be reduced by the incorporated PEG to enhance the ductility of the nanofibers. The SEM images and the MTT results demonstrated that composite fibers are suitable scaffolds for cell adhesion and proliferation. Dexamethasone (DEX), an osteogenic inducer, was loaded to PLA/MWCNT/PEG fibers. The surface element analysis performed by XPS showed that fluorine of DEX in pristine PLA fibers was much higher than those of the MWCNT-containing fibers, suggesting that the pristine PLA fibers mainly load DEX on their surfaces, whereas MWCNTs can adsorb DEX with evenly distribution in nanofibers. Drug release experiments demonstrated that the release profiles of DEX were manipulated by the ratio of PEG, and that the more PEG in the nanofibers, the faster DEX was released. When rat bone marrow stromal cells (rBMSCs) were seeded on these nanofibers, the Alizarin Red S staining and calcium quantification results demonstrated that loaded DEX were released to promote osteogenic differentiation of rBMSCs and facilitate mineralized tissue formation. These results indicated that the DEX-loaded PLA/MWCNT/PEG nanofibers not only enhanced mechanical strength, but also promoted osteogenesis of stem cells via the continuous release of DEX. The nanofibers should be a potential scaffold for bone tissue engineering application. View Full-Text
Keywords: electrospinning; dexamethasone; multi-wall carbon nanotubes; drug-loaded scaffolds; polylactic acid; polyethylene glycol; bone tissue engineering; osteogenic differentiation electrospinning; dexamethasone; multi-wall carbon nanotubes; drug-loaded scaffolds; polylactic acid; polyethylene glycol; bone tissue engineering; osteogenic differentiation
Show Figures

Graphical abstract

MDPI and ACS Style

Wang, S.-F.; Wu, Y.-C.; Cheng, Y.-C.; Hu, W.-W. The Development of Polylactic Acid/Multi-Wall Carbon Nanotubes/Polyethylene Glycol Scaffolds for Bone Tissue Regeneration Application. Polymers 2021, 13, 1740. https://doi.org/10.3390/polym13111740

AMA Style

Wang S-F, Wu Y-C, Cheng Y-C, Hu W-W. The Development of Polylactic Acid/Multi-Wall Carbon Nanotubes/Polyethylene Glycol Scaffolds for Bone Tissue Regeneration Application. Polymers. 2021; 13(11):1740. https://doi.org/10.3390/polym13111740

Chicago/Turabian Style

Wang, Shih-Feng, Yun-Chung Wu, Yu-Che Cheng, and Wei-Wen Hu. 2021. "The Development of Polylactic Acid/Multi-Wall Carbon Nanotubes/Polyethylene Glycol Scaffolds for Bone Tissue Regeneration Application" Polymers 13, no. 11: 1740. https://doi.org/10.3390/polym13111740

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop