Polymers, Volume 13, Issue 11
June-1 2021 - 229 articles
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Cover Story: Endoscopic submucosal dissection (ESD) is a surgical procedure to remove lesions in the gastrointestinal tract. A submucosal fluid cushion (SFC), such as normal saline, is used to prevent perforation; however, its cushioning maintenance is insufficient for surgery. In this study, we introduce an injectable thermosensitive chitosan solution (CS) with β-glycerophosphate (β-GP) as an SFC for ESD. The CS/β-GP solution showed viscosity change at 36.5 ℃ with acceptable injectability and biocompatibility similar to commercial products. A preclinical study presented high cushioning maintenance of the solution. These results indicate that the CS/β-GP solution might be used as an SFC in ESD. View this paper.