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Open AccessArticle

Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation

1
Department of Chemistry, Rutgers University-Camden, 315 Penn Street, Camden, NJ 08102, USA
2
Department of Physics, Rutgers University-Camden, 227 Penn Street, Camden, NJ 08102, USA
3
Department of Materials Science and Engineering, University of Virginia, Thornton Hall, P.O. Box 400259, Charlottesville, VA 22904, USA
4
Center for Computational and Integrative Biology, Rutgers University-Camden, Camden, NJ 08102, USA
*
Author to whom correspondence should be addressed.
Denotes equal contribution.
Polymers 2020, 12(10), 2381; https://doi.org/10.3390/polym12102381
Received: 26 September 2020 / Revised: 13 October 2020 / Accepted: 13 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue Metal Nanoparticles-Polymer Hybrid Materials)
The self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, results in a versatile system for a variety of applications including drug delivery and microreactors. In this study, we show that the incorporation of hydrophobic plasmonic nanoparticles within the polymersome membrane facilitates light-stimulated release of vesicle encapsulants. This work seeks to achieve tunable, triggered release with non-invasive, spatiotemporal control using single-pulse irradiation. Gold nanoparticles (AuNPs) are incorporated as photosensitizers into the hydrophobic membrane of micron-scale polymersomes and the cargo release profile is controlled by varying the pulse energy and nanoparticle concentration. We have demonstrated the ability to achieve immediate vesicle rupture as well as vesicle poration resulting in temporal cargo diffusion. Additionally, changing the pulse duration, from femtosecond to nanosecond, provides mechanistic insight into the photothermal and photomechanical contributors that govern membrane disruption in this polymer–nanoparticle hybrid system. View Full-Text
Keywords: polymersomes; vesicles; nanoparticles; drug-delivery; ultrafast laser; plasmonic; nanobubble; fragmentation polymersomes; vesicles; nanoparticles; drug-delivery; ultrafast laser; plasmonic; nanobubble; fragmentation
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MDPI and ACS Style

DiSalvo, G.M.; Robinson, A.R.; Aly, M.S.; Hoglund, E.R.; O’Malley, S.M.; Griepenburg, J.C. Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation. Polymers 2020, 12, 2381.

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