Next Article in Journal
Nanocelluloses: Natural-Based Materials for Fiber-Reinforced Cement Composites. A Critical Review
Next Article in Special Issue
Simulation Studies on the Effect of Material Characteristics and Runners Layout Geometry on the Filling Imbalance in Geometrically Balanced Injection Molds
Previous Article in Journal
Slow Dynamics of Ring Polymer Melts by Asymmetric Interaction of Threading Configuration: Monte Carlo Study of a Dynamically Constrained Lattice Model
Previous Article in Special Issue
Vegetable Tannin as a Sustainable UV Stabilizer for Polyurethane Foams
Open AccessArticle

Effect of Polyethylene Glycol Content and Molar Mass on Injection Molding of Hydroxypropyl Methylcellulose Acetate Succinate-Based Gastroresistant Capsular Devices for Oral Drug Delivery

1
Dipartimento di Chimica, Materiali e Ingegneria Chimica “G. Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
2
Dipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche “Maria Edvige Sangalli”, Università degli Studi di Milano, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Polymers 2019, 11(3), 517; https://doi.org/10.3390/polym11030517
Received: 15 February 2019 / Revised: 13 March 2019 / Accepted: 13 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Foaming and Injection Moulding in Polymer Processing)
Capsular devices for oral drug delivery were recently proposed and manufactured by injection molding (IM) as an evolution of traditional reservoir systems comprising a core and a functional coating. IM allowed the fabrication of capsule shells with release-controlling features based on the employed materials and the design characteristics. These features are independent of the drug, with significant savings in development time and costs. In previous work, IM was used to produce enteric-soluble capsules from blends of hydroxypropyl methylcellulose acetate succinate, with polyethylene glycol (PEG) as the plasticizer. In this work, the range of plasticizer concentrations and molar mass was broadened to evaluate in-depth how those parameters affect material processability and capsule performance over time. As expected, increasing the amount of the low molar mass plasticizer decreased the viscosity and modulus of the material. This simplified the molding process and enhanced the mechanical resistance of the shell, as observed during assembly. However, some samples turned out translucent, depending on several factors including storage conditions. This was attributed to plasticizer migration issues. Such results indicate that higher molar mass PEGs, while not significantly impacting on processability, lead to capsular devices with consistent performance in the investigated time lapse. View Full-Text
Keywords: HPMCAS; PEG; plasticization; injection molding; drug delivery; gastric resistance; capsular device HPMCAS; PEG; plasticization; injection molding; drug delivery; gastric resistance; capsular device
Show Figures

Graphical abstract

MDPI and ACS Style

Briatico-Vangosa, F.; Melocchi, A.; Uboldi, M.; Gazzaniga, A.; Zema, L.; Maroni, A. Effect of Polyethylene Glycol Content and Molar Mass on Injection Molding of Hydroxypropyl Methylcellulose Acetate Succinate-Based Gastroresistant Capsular Devices for Oral Drug Delivery. Polymers 2019, 11, 517.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop