PRMT5: An Emerging Target for Pancreatic Adenocarcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. Clinical Challenges with the Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)
3. Protein Arginine Methyltransferase 5 as a Potential Novel Target
4. Decoding the Mechanisms of Action of PRMT5 Inhibitor in Cancers
4.1. p53/MDM4 Axis
4.2. AKT/GSK3β/β-Catenin Axis
4.3. FBXW7/c-Myc Axis
5. PRMT5 and Alternative Splicing: Potential Key Mechanism of Action of PRMT5 Inhibitors
6. Potential Selective Predictive Response Biomarkers
7. PRMT5 Inhibition and Its Implications for Tumour Microenvironment
8. Discussion
9. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Lee, M.K.C.; Grimmond, S.M.; McArthur, G.A.; Sheppard, K.E. PRMT5: An Emerging Target for Pancreatic Adenocarcinoma. Cancers 2021, 13, 5136. https://doi.org/10.3390/cancers13205136
Lee MKC, Grimmond SM, McArthur GA, Sheppard KE. PRMT5: An Emerging Target for Pancreatic Adenocarcinoma. Cancers. 2021; 13(20):5136. https://doi.org/10.3390/cancers13205136
Chicago/Turabian StyleLee, Michael K. C., Sean M. Grimmond, Grant A. McArthur, and Karen E. Sheppard. 2021. "PRMT5: An Emerging Target for Pancreatic Adenocarcinoma" Cancers 13, no. 20: 5136. https://doi.org/10.3390/cancers13205136