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Magnetically Guided Localization Using a Guiding-Marker System® and a Handheld Magnetic Probe for Nonpalpable Breast Lesions: A Multicenter Feasibility Study in Japan

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Department of Breast Surgery and Oncology, Nippon Medical School Hospital, Tokyo 113-8603, Japan
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Division of Breast Surgical Oncology, Department of Surgery, Showa University School of Medicine, Tokyo 142-8666, Japan
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Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
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Division of Breast Surgical Oncology, Department of Surgery, Showa University Fujigaoka Hospital, Kanagawa 227-8501, Japan
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Department of Diagnostic Pathology, Nippon Medical School Hospital, Tokyo 113-8603, Japan
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Center for Data Science, Yokohama City University, Yokohama 236-0027, Japan
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Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan
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School of Engineering, Tohoku University, Miyagi 980-8579, Japan
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Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan
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Department of Research and Development, Matrix Cell Research Institute Inc., Tokyo 101-0025, Japan
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Author to whom correspondence should be addressed.
Academic Editor: David Hardisson
Cancers 2021, 13(12), 2923; https://doi.org/10.3390/cancers13122923
Received: 4 May 2021 / Revised: 31 May 2021 / Accepted: 8 June 2021 / Published: 11 June 2021
In this multicenter feasibility study, non-palpable breast lesions in 89 patients were localized using a handheld cordless magnetic probe (TAKUMI) and a magnetic marker (Guiding-Marker System®). Additionally, a dye was injected subcutaneously under ultrasound guidance to indicate the extent of the tumor. Consequently, a magnetic marker was detected in all resected specimens, and the initial surgical margin was positive only in five (6.1%) of 82 patients. Thus, the magnetic guiding localization system with ultrasound guidance is useful for the detection and excision of non-palpable breast lesions.
Accurate pre-operative localization of nonpalpable lesions plays a pivotal role in guiding breast-conserving surgery (BCS). In this multicenter feasibility study, nonpalpable breast lesions were localized using a handheld magnetic probe (TAKUMI) and a magnetic marker (Guiding-Marker System®). The magnetic marker was preoperatively placed within the target lesion under ultrasound or stereo-guidance. Additionally, a dye was injected subcutaneously to indicate the extent of the tumor excision. Surgeons checked for the marker within the lesion using a magnetic probe. The magnetic probe could detect the guiding marker and accurately localize the target lesion intraoperatively. All patients with breast cancer underwent wide excision with a safety margin of ≥5 mm. The presence of the guiding-marker within the resected specimen was the primary outcome and the pathological margin status and re-excision rate were the secondary outcomes. Eighty-seven patients with nonpalpable lesions who underwent BCS, from January to March of 2019 and from January to July of 2020, were recruited. The magnetic marker was detected in all resected specimens. The surgical margin was positive only in 5/82 (6.1%) patients; these patients underwent re-excision. This feasibility study demonstrated that the magnetic guiding localization system is useful for the detection and excision of nonpalpable breast lesions. View Full-Text
Keywords: nonpalpable breast lesion; breast cancer; magnetic maker; magnetic probe; surgery nonpalpable breast lesion; breast cancer; magnetic maker; magnetic probe; surgery
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MDPI and ACS Style

Kurita, T.; Taruno, K.; Nakamura, S.; Takei, H.; Enokido, K.; Kuwayama, T.; Kanada, Y.; Akashi-Tanaka, S.; Matsuyanagi, M.; Hankyo, M.; Yanagihara, K.; Sakatani, T.; Sakamaki, K.; Kuwahata, A.; Sekino, M.; Kusakabe, M. Magnetically Guided Localization Using a Guiding-Marker System® and a Handheld Magnetic Probe for Nonpalpable Breast Lesions: A Multicenter Feasibility Study in Japan. Cancers 2021, 13, 2923. https://doi.org/10.3390/cancers13122923

AMA Style

Kurita T, Taruno K, Nakamura S, Takei H, Enokido K, Kuwayama T, Kanada Y, Akashi-Tanaka S, Matsuyanagi M, Hankyo M, Yanagihara K, Sakatani T, Sakamaki K, Kuwahata A, Sekino M, Kusakabe M. Magnetically Guided Localization Using a Guiding-Marker System® and a Handheld Magnetic Probe for Nonpalpable Breast Lesions: A Multicenter Feasibility Study in Japan. Cancers. 2021; 13(12):2923. https://doi.org/10.3390/cancers13122923

Chicago/Turabian Style

Kurita, Tomoko, Kanae Taruno, Seigo Nakamura, Hiroyuki Takei, Katsutoshi Enokido, Takashi Kuwayama, Yoko Kanada, Sadako Akashi-Tanaka, Misaki Matsuyanagi, Meishi Hankyo, Keiko Yanagihara, Takashi Sakatani, Kentaro Sakamaki, Akihiro Kuwahata, Masaki Sekino, and Moriaki Kusakabe. 2021. "Magnetically Guided Localization Using a Guiding-Marker System® and a Handheld Magnetic Probe for Nonpalpable Breast Lesions: A Multicenter Feasibility Study in Japan" Cancers 13, no. 12: 2923. https://doi.org/10.3390/cancers13122923

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