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The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis

by 1,†, 2,†,‡, 1,‡, 1,*,† and 2,3,*,†
1
Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge CB20QQ, UK
2
Department of Pathology, Medical University Vienna, 1090 Vienna, Austria
3
Ludwig Boltzmann Institute Applied Diagnostics, 1090 Vienna, Austria
*
Authors to whom correspondence should be addressed.
European Research Initiative for ALK-related malignancies; www.erialcl.net.
These authors contributed equally to this work.
Cancers 2019, 11(8), 1074; https://doi.org/10.3390/cancers11081074
Received: 7 June 2019 / Revised: 17 July 2019 / Accepted: 23 July 2019 / Published: 30 July 2019
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase involved in neuronal and gut development. Initially discovered in T cell lymphoma, ALK is frequently affected in diverse cancers by oncogenic translocations. These translocations involve different fusion partners that facilitate multimerisation and autophosphorylation of ALK, resulting in a constitutively active tyrosine kinase with oncogenic potential. ALK fusion proteins are involved in diverse cellular signalling pathways, such as Ras/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K)/Akt and Janus protein tyrosine kinase (JAK)/STAT. Furthermore, ALK is implicated in epigenetic regulation, including DNA methylation and miRNA expression, and an interaction with nuclear proteins has been described. Through these mechanisms, ALK fusion proteins enable a transcriptional programme that drives the pathogenesis of a range of ALK-related malignancies. View Full-Text
Keywords: ALK; ALCL; NPM-ALK; EML4-ALK; NSCLC; ALK-translocation proteins; epigenetics ALK; ALCL; NPM-ALK; EML4-ALK; NSCLC; ALK-translocation proteins; epigenetics
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MDPI and ACS Style

Ducray, S.P.; Natarajan, K.; Garland, G.D.; Turner, S.D.; Egger, G. The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis. Cancers 2019, 11, 1074. https://doi.org/10.3390/cancers11081074

AMA Style

Ducray SP, Natarajan K, Garland GD, Turner SD, Egger G. The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis. Cancers. 2019; 11(8):1074. https://doi.org/10.3390/cancers11081074

Chicago/Turabian Style

Ducray, Stephen P.; Natarajan, Karthikraj; Garland, Gavin D.; Turner, Suzanne D.; Egger, Gerda. 2019. "The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis" Cancers 11, no. 8: 1074. https://doi.org/10.3390/cancers11081074

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