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B Cells as an Immune-Regulatory Signature in Ovarian Cancer

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
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Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 894; https://doi.org/10.3390/cancers11070894
Received: 3 June 2019 / Revised: 20 June 2019 / Accepted: 22 June 2019 / Published: 26 June 2019
(This article belongs to the Special Issue Ovarian Cancer Metastasis)
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Abstract

Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the tumor microenvironment determine tumor progression. While the regulatory functions of T cells among tumor-infiltrating lymphocytes are well defined and also involve therapeutic interventions, the role of B cells in ovarian cancer progression is still limited to their impact on survival. Recent studies have identified both pro- and anti-tumor responses of B cells in solid tumors, as different subsets of B cells play diverse roles in progression. Thus, in-depth characterization of B cell subtypes in each disease stage is crucial for understanding the importance and therapeutic potential of these cells in ovarian cancer. In this review, we summarize current knowledge about B cells in ovarian cancer and discuss emerging therapeutic interventions that could harness B cells to combat this deadly disease. View Full-Text
Keywords: ovarian cancer; B cells; tumor microenvironment; immune cells; tumor infiltrating lymphocytes ovarian cancer; B cells; tumor microenvironment; immune cells; tumor infiltrating lymphocytes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gupta, P.; Chen, C.; Chaluvally-Raghavan, P.; Pradeep, S. B Cells as an Immune-Regulatory Signature in Ovarian Cancer. Cancers 2019, 11, 894.

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