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B Cells as an Immune-Regulatory Signature in Ovarian Cancer

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 894;
Received: 3 June 2019 / Revised: 20 June 2019 / Accepted: 22 June 2019 / Published: 26 June 2019
(This article belongs to the Special Issue Ovarian Cancer Metastasis)
PDF [500 KB, uploaded 27 June 2019]
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Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the tumor microenvironment determine tumor progression. While the regulatory functions of T cells among tumor-infiltrating lymphocytes are well defined and also involve therapeutic interventions, the role of B cells in ovarian cancer progression is still limited to their impact on survival. Recent studies have identified both pro- and anti-tumor responses of B cells in solid tumors, as different subsets of B cells play diverse roles in progression. Thus, in-depth characterization of B cell subtypes in each disease stage is crucial for understanding the importance and therapeutic potential of these cells in ovarian cancer. In this review, we summarize current knowledge about B cells in ovarian cancer and discuss emerging therapeutic interventions that could harness B cells to combat this deadly disease. View Full-Text
Keywords: ovarian cancer; B cells; tumor microenvironment; immune cells; tumor infiltrating lymphocytes ovarian cancer; B cells; tumor microenvironment; immune cells; tumor infiltrating lymphocytes

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Gupta, P.; Chen, C.; Chaluvally-Raghavan, P.; Pradeep, S. B Cells as an Immune-Regulatory Signature in Ovarian Cancer. Cancers 2019, 11, 894.

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