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Open AccessArticle

Features in Microfluidic Paper-Based Devices Made by Laser Cutting: How Small Can They Be?

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Faculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON L1H 7K4, Canada
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ExVivo Labs Inc., 3 Regina Street North, Suite A, Waterloo, ON N2J 2Z7, Canada
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Author to whom correspondence should be addressed.
Micromachines 2018, 9(5), 220; https://doi.org/10.3390/mi9050220
Received: 9 April 2018 / Revised: 25 April 2018 / Accepted: 4 May 2018 / Published: 7 May 2018
(This article belongs to the Section B:Biology)
In this paper, we determine the smallest feature size that enables fluid flow in microfluidic paper-based analytical devices (µPADs) fabricated by laser cutting. The smallest feature sizes fabricated from five commercially available paper types: Whatman filter paper grade 50 (FP-50), Whatman 3MM Chr chromatography paper (3MM Chr), Whatman 1 Chr chromatography paper (1 Chr), Whatman regenerated cellulose membrane 55 (RC-55) and Amershan Protran 0.45 nitrocellulose membrane (NC), were 139 ± 8 µm, 130 ± 11 µm, 103 ± 12 µm, 45 ± 6 µm, and 24 ± 3 µm, respectively, as determined experimentally by successful fluid flow. We found that the fiber width of the paper correlates with the smallest feature size that has the capacity for fluid flow. We also investigated the flow speed of Allura red dye solution through small-scale channels fabricated from different paper types. We found that the flow speed is significantly slower through microscale features and confirmed the similar trends that were reported previously for millimeter-scale channels, namely that wider channels enable quicker flow speed. View Full-Text
Keywords: paper-based devices; microfluidics; miniaturization; wicking; compact µPADs paper-based devices; microfluidics; miniaturization; wicking; compact µPADs
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MDPI and ACS Style

Mahmud, M.A.; Blondeel, E.J.M.; Kaddoura, M.; MacDonald, B.D. Features in Microfluidic Paper-Based Devices Made by Laser Cutting: How Small Can They Be? Micromachines 2018, 9, 220.

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