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Challenges in the Use of Compact Disc-Based Centrifugal Microfluidics for Healthcare Diagnostics at the Extreme Point of Care

Mechanical Engineering Department, Clemson University, Clemson, SC 29634, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Marc Madou
Micromachines 2016, 7(4), 52;
Received: 17 December 2015 / Revised: 15 February 2016 / Accepted: 22 February 2016 / Published: 24 March 2016
(This article belongs to the Special Issue Centrifugal (Compact-Disc) Microfluidics for Extreme POC)
PDF [7606 KB, uploaded 24 March 2016]


Since its inception, Compact Disc (CD)-based centrifugal microfluidic technology has drawn a great deal of interest within research communities due to its potential use in biomedical applications. The technology has been referred to by different names, including compact-disc microfluidics, lab-on-a-disk, lab-on-a-CD and bio-disk. This paper critically reviews the state-of-the-art in CD-based centrifugal microfluidics devices and attempts to identify the challenges that, if solved, would enable their use in the extreme point of care. Sample actuation, manufacturing, reagent storage and implementation, target multiplexing, bio-particle detection, required hardware and system disposal, and sustainability are the topics of focus. View Full-Text
Keywords: centrifugal; microfluidics; point of care; diagnostic; lab-on-disk centrifugal; microfluidics; point of care; diagnostic; lab-on-disk

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Gilmore, J.; Islam, M.; Martinez-Duarte, R. Challenges in the Use of Compact Disc-Based Centrifugal Microfluidics for Healthcare Diagnostics at the Extreme Point of Care. Micromachines 2016, 7, 52.

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