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Article

Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations

1
Mechanical Engineering Program, Graduate School of Science Engineering and Technology, Istanbul Technical University, Maslak, 34496 Istanbul, Turkey
2
Mechanical Engineering Department, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Uskudar, 34700 Istanbul, Turkey
3
Sabanci University Nanotechnology Research Center (SUNUM), Sabanci University, Tuzla, 34956 Istanbul, Turkey
4
Center of Excellence for Functional Surfaces and Interfaces for Nanodiagnostics (EFSUN), Faculty of Engineering and Natural Sciences, Sabanci University, Tuzla, 34956 Istanbul, Turkey
5
Mechanical Engineering Department, Faculty of Mechanical Engineering, Istanbul Technical University, Gumussuyu, 34437 Istanbul, Turkey
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(4), 412; https://doi.org/10.3390/mi11040412
Received: 22 March 2020 / Revised: 8 April 2020 / Accepted: 9 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue Inertial Microfluidics)
Label-free, size-dependent cell-sorting applications based on inertial focusing phenomena have attracted much interest during the last decade. The separation capability heavily depends on the precision of microparticle focusing. In this study, five-loop spiral microchannels with a height of 90 µm and a width of 500 µm are introduced. Unlike their original spiral counterparts, these channels have elliptic configurations of varying initial aspect ratios, namely major axis to minor axis ratios of 3:2, 11:9, 9:11, and 2:3. Accordingly, the curvature of these configurations increases in a curvilinear manner through the channel. The effects of the alternating curvature and channel Reynolds number on the focusing of fluorescent microparticles with sizes of 10 and 20 µm in the prepared suspensions were investigated. At volumetric flow rates between 0.5 and 3.5 mL/min (allowing separation), each channel was tested to collect samples at the designated outlets. Then, these samples were analyzed by counting the particles. These curved channels were capable of separating 20 and 10 µm particles with total yields up to approximately 95% and 90%, respectively. The results exhibited that the level of enrichment and the focusing behavior of the proposed configurations are promising compared to the existing microfluidic channel configurations. View Full-Text
Keywords: inertial focusing; microfluidics; spiral microchannels; fluorescent particle separation inertial focusing; microfluidics; spiral microchannels; fluorescent particle separation
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MDPI and ACS Style

Erdem, K.; Ahmadi, V.E.; Kosar, A.; Kuddusi, L. Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations. Micromachines 2020, 11, 412. https://doi.org/10.3390/mi11040412

AMA Style

Erdem K, Ahmadi VE, Kosar A, Kuddusi L. Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations. Micromachines. 2020; 11(4):412. https://doi.org/10.3390/mi11040412

Chicago/Turabian Style

Erdem, Kaan, Vahid E. Ahmadi, Ali Kosar, and Lütfullah Kuddusi. 2020. "Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations" Micromachines 11, no. 4: 412. https://doi.org/10.3390/mi11040412

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