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Reusable Embedded Microcoils for Magnetic Nano-Beads Trapping in Microfluidics: Magnetic Simulation and Experiments

1
Université Paris-Saclay, CNRS, Centre de Nanosciences et de Nanotechnologies, 91120 Palaiseau, France
2
School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi 10000, Vietnam
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(3), 257; https://doi.org/10.3390/mi11030257
Received: 25 November 2019 / Revised: 19 February 2020 / Accepted: 21 February 2020 / Published: 28 February 2020
(This article belongs to the Section A:Physics)
In this study, a microfluidic chip with integrated coil was designed and fabricated for the aim of effectively trapping magnetic nanobeads (Adembeads®, 300 nm) and measuring the chip’s temperature during the working time. In addition, a reversible technique of bonding Polydimethylsiloxane (PDMS) channels was presented. This bonding process used a coating layer of CYTOP®product as a protection, insulation and low-adhesion layer. The reversible packaging technique allows the bottom substrate to be reused, possibly equipped with sensors, and to use a disposable microchannels network. The FE method was employed to calculate the magnetic field and power consumption by the ANSYS® version 12.1 software. Merit factors were defined in order to synthetically represent the ability of the simulated coil to trap beads for a unit power consumption, i.e. a given heat generation. The simulation results propose a new approach to optimize the design criteria in fabricating planar microcoils. The optimal microcoils were fabricated and then used to realize a magnetic immunoassay in a microfluidic chip. The aim was to integrate these microcoils into a lab-on-chip and obtain a fast and highly sensitive biological element detection. View Full-Text
Keywords: planar microcoils; microfluidics; polydimethylsiloxane (PDMS); magnetic beads trapping; magnetic field simulation planar microcoils; microfluidics; polydimethylsiloxane (PDMS); magnetic beads trapping; magnetic field simulation
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MDPI and ACS Style

Lefebvre, O.; Cao, H.H.; Cortés Francisco, M.; Woytasik, M.; Dufour-Gergam, E.; Ammar, M.; Martincic, E. Reusable Embedded Microcoils for Magnetic Nano-Beads Trapping in Microfluidics: Magnetic Simulation and Experiments. Micromachines 2020, 11, 257. https://doi.org/10.3390/mi11030257

AMA Style

Lefebvre O, Cao HH, Cortés Francisco M, Woytasik M, Dufour-Gergam E, Ammar M, Martincic E. Reusable Embedded Microcoils for Magnetic Nano-Beads Trapping in Microfluidics: Magnetic Simulation and Experiments. Micromachines. 2020; 11(3):257. https://doi.org/10.3390/mi11030257

Chicago/Turabian Style

Lefebvre, Olivier, Hong H. Cao, Meritxell Cortés Francisco, Marion Woytasik, Elisabeth Dufour-Gergam, Mehdi Ammar, and Emile Martincic. 2020. "Reusable Embedded Microcoils for Magnetic Nano-Beads Trapping in Microfluidics: Magnetic Simulation and Experiments" Micromachines 11, no. 3: 257. https://doi.org/10.3390/mi11030257

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