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Open AccessArticle

Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays

1
Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 08826, Korea
2
Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Korea
3
Interdisciplinary Program for Bioengineering, Seoul National University, Seoul 08826, Korea
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Department of Material Science and Engineering, Seoul National University, Seoul 08826, Korea
5
School of Environmental Engineering, University of Seoul, Seoul 08826, Korea
6
BK21+ Creative Research Engineer Development for IT, Seoul National University, Seoul 08826, Korea
7
School of Materials Science and Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea
*
Authors to whom correspondence should be addressed.
These authors equally contributed to this work.
Micromachines 2020, 11(2), 175; https://doi.org/10.3390/mi11020175
Received: 6 December 2019 / Revised: 29 January 2020 / Accepted: 4 February 2020 / Published: 7 February 2020
(This article belongs to the Special Issue Microfluidics for Healthcare Based Applications)
The need for high-throughput screening has led to the miniaturization of the reaction volume of the chamber in bioassays. As the reactor gets smaller, surface tension dominates the gravitational or inertial force, and mixing efficiency decreases in small-scale reactions. Because passive mixing by simple diffusion in tens of microliter-scale volumes takes a long time, active mixing is needed. Here, we report an efficient micromixing method using magnetically rotating microparticles with patterned magnetization induced by magnetic nanoparticle chains. Because the microparticles have magnetization patterning due to fabrication with magnetic nanoparticle chains, the microparticles can rotate along the external rotating magnetic field, causing micromixing. We validated the reaction efficiency by comparing this micromixing method with other mixing methods such as simple diffusion and the use of a rocking shaker at various working volumes. This method has the potential to be widely utilized in suspension assay technology as an efficient mixing strategy.
Keywords: microparticle; micromixing; magnetic particle; magnetization patterning; suspension array microparticle; micromixing; magnetic particle; magnetization patterning; suspension array
MDPI and ACS Style

Kim, S.D.; Song, S.W.; Oh, D.Y.; Lee, A.C.; Koo, J.W.; Kang, T.; Kim, M.C.; Lee, C.; Jeong, Y.; Jeong, H.Y.; Lee, D.; Cho, S.; Kwon, S.; Kim, J. Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays. Micromachines 2020, 11, 175.

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