Next Article in Journal
Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays
Previous Article in Journal
Actuation Mechanism of Microvalves: A Review
Open AccessArticle

Additive Manufacturing of Micromanipulator Mounted on a Glass Capillary for Biological Applications

1
Graduate school of Engineering Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama 240-8501, Japan
2
College of Engineering Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama 240-8501, Japan
3
Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama 240-8501, Japan
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(2), 174; https://doi.org/10.3390/mi11020174
Received: 17 January 2020 / Revised: 3 February 2020 / Accepted: 6 February 2020 / Published: 7 February 2020
(This article belongs to the Special Issue Microscale Robotics for Cellular and Tissue Engineering)
In this study, a three-dimensional (3D) micromanipulator mounted on a glass capillary is developed for handling biological samples, such as multicellular spheroids and embryos. To fabricate the micromanipulator, we developed an additive manufacturing system based on high-resolution microstereolithography using a 405-nm blue laser. The fabrication system makes it possible to fabricate 3D microstructures on a glass capillary with 2.5 µm lateral resolution and 25 µm layer thickness. We also demonstrated the capture and release of a spheroid with the micromanipulator fabricated using our additive manufacturing system. We showed that spheroids can be easily handled by a simple operation with minimal damage using a cage-like multiple finger structure. Additive manufacturing of tailor-made micromanipulators mounted on a glass capillary will be useful in biological and tissue engineering research.
Keywords: microstereolithography; 3D printing; additive manufacturing; photo-curable polymer; micromanipulation; microtweezers; compliant mechanism. microstereolithography; 3D printing; additive manufacturing; photo-curable polymer; micromanipulation; microtweezers; compliant mechanism.
Show Figures

Graphical abstract

MDPI and ACS Style

Kozaki, S.; Moritoki, Y.; Furukawa, T.; Akieda, H.; Kageyama, T.; Fukuda, J.; Maruo, S. Additive Manufacturing of Micromanipulator Mounted on a Glass Capillary for Biological Applications. Micromachines 2020, 11, 174.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop