Next Article in Journal
Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays
Next Article in Special Issue
Design, Fabrication, and Validation of a Petri Dish-Compatible PDMS Bioreactor for the Tensile Stimulation and Characterization of Microtissues
Previous Article in Journal
Actuation Mechanism of Microvalves: A Review
Article

Additive Manufacturing of Micromanipulator Mounted on a Glass Capillary for Biological Applications

1
Graduate School of Engineering Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama 240-8501, Japan
2
College of Engineering Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama 240-8501, Japan
3
Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama 240-8501, Japan
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(2), 174; https://doi.org/10.3390/mi11020174
Received: 17 January 2020 / Revised: 3 February 2020 / Accepted: 6 February 2020 / Published: 7 February 2020
(This article belongs to the Special Issue Microscale Robotics for Cellular and Tissue Engineering)
In this study, a three-dimensional (3D) micromanipulator mounted on a glass capillary is developed for handling biological samples, such as multicellular spheroids and embryos. To fabricate the micromanipulator, we developed an additive manufacturing system based on high-resolution microstereolithography using a 405-nm blue laser. The fabrication system makes it possible to fabricate 3D microstructures on a glass capillary with 2.5 µm lateral resolution and 25 µm layer thickness. We also demonstrated the capture and release of a spheroid with the micromanipulator fabricated using our additive manufacturing system. We showed that spheroids can be easily handled by a simple operation with minimal damage using a cage-like multiple finger structure. Additive manufacturing of tailor-made micromanipulators mounted on a glass capillary will be useful in biological and tissue engineering research. View Full-Text
Keywords: microstereolithography; 3D printing; additive manufacturing; photo-curable polymer; micromanipulation; microtweezers; compliant mechanism microstereolithography; 3D printing; additive manufacturing; photo-curable polymer; micromanipulation; microtweezers; compliant mechanism
Show Figures

Graphical abstract

MDPI and ACS Style

Kozaki, S.; Moritoki, Y.; Furukawa, T.; Akieda, H.; Kageyama, T.; Fukuda, J.; Maruo, S. Additive Manufacturing of Micromanipulator Mounted on a Glass Capillary for Biological Applications. Micromachines 2020, 11, 174. https://doi.org/10.3390/mi11020174

AMA Style

Kozaki S, Moritoki Y, Furukawa T, Akieda H, Kageyama T, Fukuda J, Maruo S. Additive Manufacturing of Micromanipulator Mounted on a Glass Capillary for Biological Applications. Micromachines. 2020; 11(2):174. https://doi.org/10.3390/mi11020174

Chicago/Turabian Style

Kozaki, Shingo, Yukihito Moritoki, Taichi Furukawa, Hikaru Akieda, Tatsuto Kageyama, Junji Fukuda, and Shoji Maruo. 2020. "Additive Manufacturing of Micromanipulator Mounted on a Glass Capillary for Biological Applications" Micromachines 11, no. 2: 174. https://doi.org/10.3390/mi11020174

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop