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Open AccessCommunication

Auxiliary Optomechanical Tools for 3D Cell Manipulation

by 1,2,3,*, 2,3, 3,4,5 and 2,3
Faculty of Physics and Engineering, ITMO University, Lomonosova 9, 191002 St. Petersburg, Russia
School of Electrical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
Light-Matter Interaction Centre, Tel Aviv University, Tel Aviv 69978, Israel
School of Chemistry, Tel Aviv University, Tel Aviv 69978, Israel
School of Physics & Astronomy, Tel Aviv University, Tel Aviv 69978, Israel
Author to whom correspondence should be addressed.
Micromachines 2020, 11(1), 90;
Received: 7 November 2019 / Revised: 30 December 2019 / Accepted: 9 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue Optical Trapping and Manipulation: From Fundamentals to Applications)
Advances in laser and optoelectronic technologies have brought the general concept of optomechanical manipulation to the level of standard biophysical tools, paving the way towards controlled experiments and measurements of tiny mechanical forces. Recent developments in direct laser writing (DLW) have enabled the realization of new types of micron-scale optomechanical tools, capable of performing designated functions. Here we further develop the concept of DLW-fabricated optomechanically-driven tools and demonstrate full-3D manipulation capabilities over biological objects. In particular, we resolved the long-standing problem of out-of-plane rotation in a pure liquid, which was demonstrated on a living cell, clamped between a pair of forks, designed for efficient manipulation with holographic optical tweezers. The demonstrated concept paves the way for the realization of flexible tools for performing on-demand functions over biological objects, such as cell tomography and surgery to name just few. View Full-Text
Keywords: holographic optical trapping; direct laser writing holographic optical trapping; direct laser writing
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MDPI and ACS Style

Shishkin, I.; Markovich, H.; Roichman, Y.; Ginzburg, P. Auxiliary Optomechanical Tools for 3D Cell Manipulation. Micromachines 2020, 11, 90.

AMA Style

Shishkin I, Markovich H, Roichman Y, Ginzburg P. Auxiliary Optomechanical Tools for 3D Cell Manipulation. Micromachines. 2020; 11(1):90.

Chicago/Turabian Style

Shishkin, Ivan; Markovich, Hen; Roichman, Yael; Ginzburg, Pavel. 2020. "Auxiliary Optomechanical Tools for 3D Cell Manipulation" Micromachines 11, no. 1: 90.

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