Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies
by
Antonela Matana 1
,
Vesela Torlak 2,
Dubravka Brdar 2,
Marijana Popović 1,
Bernarda Lozić 3,
Maja Barbalić 1,
Vesna Boraska Perica 1,
Ante Punda 2,
Ozren Polašek 4,
Caroline Hayward 5 and
Tatijana Zemunik 1,*
Antonela Matana 1,
Vesela Torlak 2,
Dubravka Brdar 2,
Marijana Popović 1,
Bernarda Lozić 3,
Maja Barbalić 1,
Vesna Boraska Perica 1,
Ante Punda 2,
Ozren Polašek 4,
Caroline Hayward 5 and
Tatijana Zemunik 1,*
1
Department of Medical Biology, School of Medicine Split, University of Split, Šoltanska 2, 21000 Split, Croatia
2
Department of Nuclear Medicine, University Hospital Split, Spinciceva 1, 21000 Split, Croatia
3
Department of Pediatrics, University Hospital Split, Spinciceva 1, 21000 Split, Croatia
4
Department of Public Health, School of Medicine Split, University of Split, Šoltanska 2 , 21000 Split, Croatia
5
MRC Human Genetics Unit, University of Edinburgh, Western General Hospital, Crewe Road, EH4 2XU Edinburgh, UK
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(11), 1186; https://doi.org/10.3390/nu9111186
Received: 12 October 2017 / Revised: 20 October 2017 / Accepted: 25 October 2017 / Published: 28 October 2017
The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab and/or Tg-Ab were defined as cases (n = 462) and those with TPO-Ab and/or Tg-Ab within referent values were defined as controls (n = 1425). Dietary intake was evaluated according to a food frequency questionnaire containing 58 food items. Principal component analysis was used to group food items into dietary groups. We used logistic regression analysis to examine dietary groups associated with positive plasma TPO-Ab and/or Tg-Ab. The results indicate that the dietary group with frequent consumption of animal fats and butter is associated with positive plasma TPO-Ab and/or Tg-Ab (p = 0.01). The dietary group with frequent consumption of vegetables as well as the dietary group with high consumption of dried fruit, nuts, and muesli are associated with negative findings of TPO-Ab and/or Tg-Ab (p = 0.048 and p = 0.02, respectively). We showed that the anti-inflammatory dietary groups are associated with the negative findings of plasma TPO-Ab and/or Tg-Ab.
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Keywords:
autoimmune thyroid diseases; thyroid peroxidase antibodies; thyroglobulin antibodies; dietary habits
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MDPI and ACS Style
Matana, A.; Torlak, V.; Brdar, D.; Popović, M.; Lozić, B.; Barbalić, M.; Perica, V.B.; Punda, A.; Polašek, O.; Hayward, C.; Zemunik, T. Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies. Nutrients 2017, 9, 1186.
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