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Open AccessArticle

Natural Course of Metabolically Healthy Overweight/Obese Subjects and the Impact of Weight Change

Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China
Department of Endocrinology and Institute of Cardiovascular Diseases, Zhejiang Putuo Hospital, Zhoushan 316100, Zhejiang, China
Tongxiang Center for Disease Control and Prevention, Tongxiang 314500, Zhejiang, China
Institute of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310000, Zhejiang, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(7), 430;
Received: 19 May 2016 / Revised: 8 July 2016 / Accepted: 11 July 2016 / Published: 15 July 2016
(This article belongs to the Special Issue Metabolically Healthy Obesity)
Few studies have described the characteristics of metabolically healthy individuals with excess fat in the Chinese population. This study aimed to prospectively investigate the natural course of metabolically healthy overweight/obese (MH-OW/OB) adults, and to assess the impact of weight change on developing metabolic abnormalities. During 2009–2010, 525 subjects without any metabolic abnormalities or other obesity-related diseases were evaluated and reevaluated after 5 years. The subjects were categorized into two groups of overweight/obese and normal weight based on the criteria of BMI by 24.0 at baseline. At follow-up, the MH-OW/OB subjects had a significantly increased risk of developing metabolically abnormalities compared with metabolically healthy normal-weight (MH-NW) individuals (risk ratio: 1.35, 95% confidence interval: 1.17–1.49, p value < 0.001). In the groups of weight gain and weight maintenance, the MH-OW/OB subjects was associated with a larger increase in fasting glucose, triglycerides, systolic blood pressure, diastolic blood pressure and decrease in high-density lipoprotein cholesterol comparing with MH-NW subjects. In the weight loss group, no significant difference of changes of metabolic parameters was observed between MH-OW/OB and MH-NW adults. This study verifies that MH-OW/OB are different from MH-NW subjects. Weight management is needed for all individuals since weight change has a significant effect on metabolic health without considering the impact of weight change according to weight status. View Full-Text
Keywords: metabolically healthy; overweight and obese; weight change metabolically healthy; overweight and obese; weight change
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MDPI and ACS Style

Zheng, R.; Liu, C.; Wang, C.; Zhou, B.; Liu, Y.; Pan, F.; Zhang, R.; Zhu, Y. Natural Course of Metabolically Healthy Overweight/Obese Subjects and the Impact of Weight Change. Nutrients 2016, 8, 430.

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